Catalase, carbonic anhydrase and other biochemical parameters in esophageal cancers in Turkey

The main aim of our investigation is to show possible changes in antioxidant balance and selected biochemical parameters in esophageal cancers.

This study was performed for the determination of levels in 25 patients diagnosed as having cancer in the Yuzuncu Yil University (Medical Oncology) and 15 healthy volunteers at same department with negative cancer signs.

The activity levels of catalase of sick and health groups were 33.8±4.31 (EU/gHg)-1, 122.4±31.7 (EU/gHg)-1, respectively. Th differance between the average levels was significant (p<0.001). CA (carbonic anhydrase) activity was 2.19±0.12 (EU/gHg)-1, 2.46±0.32 (EU/gHg)-1 in groups at same order with no statistical significance (p>0.05). The levels of albumin, globulin, ferritin, ALT, LDH, glucose, CRP, AST and uric acid were also determined in sick and healthy groups: 4.04±0.24, 4.04±0.43 gr/dl (p>0.05); 4.46±0.82, 3.17±0.10g/dl (p>0.05); 175.4±29.1, 260.4±15.45g/dI (p<0.001); 12.7±1.13, 19.5±1.91 ng/ml (p<0.001); 317.6±13.8, 298.0±12.1 mg/dl (p>0.05); 106.5±12.1, 89.7±2.2 (p>0.05), 5.94±1.04, 4.41±0.28 U/L (p>0.05); 19.4±1.68, 19.5±1.91 mg/dl (p>0.05); 30.0±3.24, 10.5±0.64 mg/dl (p<0.01) respectively.

Consequently, in diagnosis of esophageal cancer, CA, CRP, uric acid and antioxidant examinations may be very important factors. Additional studies are needed to further address this important issue.