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Gender-specific differences in the urinary expression of aldosterone, IL-1α and IL-1β
Marie M Bourgeois1, Ira S Richards
1Department of Environmental & Occupational Health, University of South Florida College of Public Health,13201 Bruce B. Downs Blvd., MDC 56, Tampa, FL, USA. mbourgeo@health.usf.edu
Aims:
This pilot investigation examined the possibility of using urine specimens to explore the difference between the expression of several biomarkers based on gender. These biomarkers include several associated with cardiac damage, oxidative stress and inflammation.
Materials & Methods:
Urine specimens were assayed for total protein, aldosterone, high-sensitivity C-reactive protein, myeloperoxidase and IL-1α and -1β using ELISA.
Results:
We observed significant differences between the sexes for aldosterone and IL-1α and -1β.
Conclusion:
The presence of gender-based differences in the urinary expression of these biomarkers may be important for establishing normal baseline values in males and females, and may prove to be of value in the development of rapid noninvasive ways to assess inflammatory and oxidative injury during routine urinalysis.
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