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Related Concept Videos

Pulmonary Function Tests01:25

Pulmonary Function Tests

Pulmonary Function Tests (PFTs)
Pulmonary Function Tests are crucial diagnostic tools for assessing respiratory function, particularly in patients with chronic respiratory disorders. They comprehensively evaluate lung volumes, ventilatory function, breathing mechanics, diffusion, and gas exchange. These tests help diagnose pulmonary diseases and play a significant role in monitoring disease progression, evaluating disability, and assessing response to therapy.
PFTs involve using a spirometer, a...

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Protocol and Guidelines for Point-of-Care Lung Ultrasound in Diagnosing Neonatal Pulmonary Diseases Based on International Expert Consensus
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Biomarker tests for fetal lung maturity.

Van Leung-Pineda1, Ann M Gronowski

  • 1Department of Pathology & Immunology, Washington University School of Medicine, 660 S. Euclid, Box 8118, St Louis, MO 63110, USA.

Biomarkers in Medicine
|December 8, 2010
PubMed
Summary

Fetal lung maturity tests predict respiratory distress syndrome. With the TDx FLM II test discontinued, this review examines alternatives like lecithin:sphingomyelin ratio and lamellar body counts for assessing infant lung development.

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Area of Science:

  • Neonatology
  • Pulmonary Medicine
  • Biochemistry

Background:

  • Surfactant production is crucial for fetal lung development, preventing alveolar collapse.
  • Inadequate surfactant leads to respiratory distress syndrome (RDS) in newborns.
  • Amniotic fluid tests predict fetal lung maturity and the likelihood of RDS.

Purpose of the Study:

  • To review current fetal lung maturity tests.
  • To evaluate the clinical utility of available methods.
  • To identify potential replacements for the discontinued TDx FLM II test.

Main Methods:

  • Review of existing literature on fetal lung maturity assays.
  • Analysis of tests including lecithin:sphingomyelin ratio, phosphatidyl glycerol, surfactant:albumin ratio, and lamellar body counts.
  • Discussion of clinical applicability and predictive value.

Main Results:

  • Lecithin:sphingomyelin ratio, phosphatidyl glycerol, surfactant:albumin ratio, and lamellar body counts are established methods for assessing fetal lung maturity.
  • These tests offer varying degrees of accuracy and clinical utility.
  • The discontinuation of TDx FLM II necessitates the evaluation of these alternatives.

Conclusions:

  • Several reliable tests exist to assess fetal lung maturity in the absence of TDx FLM II.
  • Clinical utility and accessibility should guide the choice of test.
  • Continued research is needed to optimize fetal lung maturity assessment for improved neonatal outcomes.