Good intentions: risk factors for unintended pregnancies in the US cohort of a microbicide trial
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Updated: Jun 6, 2026

A Novel Method for Involving Women of Color at High Risk for Preterm Birth in Research Priority Setting
Published on: January 12, 2018
Courtney A Schreiber1, Sara Whittington, Liyi Cen
1University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA. cschreiber@obgyn.upenn.edu
Background:
The study was conducted to assess socio-behavioral and biological factors associated with unplanned pregnancy in the US cohort of a microbicide trial.
Study Design:
We conducted a mixed-method, nested case-control study of risk factors for pregnancy within the US cohort of the microbicide trial HPTN 035. We developed an instrument to assess attitudes and beliefs about fertility control/contraceptive utilization among 122 women. Cases were HPTN 035 participants who became pregnant while enrolled, matched by time on study 1:4 with controls. Univariable and multivariable analysis were performed with pregnancy as the outcome of interest.
Results:
Contraceptive method change during the trial was associated with unplanned pregnancy (OR=1.76). Participant desire/partners' desire for future children (OR=4.95) and young age (OR=0.88 annually above age 19 years) were independently associated with unintended pregnancy.
Conclusion:
Within a trial that enroll heterosexually active women, there may be ways to identify those at highest risk of becoming pregnant a priori.
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