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Related Experiment Video

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Finite Element Modelling of a Cellular Electric Microenvironment

Finite Element Modelling of a Cellular Electric Microenvironment

Published on: May 18, 2021

Systems biology and integrative physiological modelling.

Robert L Hester¹, Radu Iliescu, Richard Summers

¹Department of Physiology, University of Mississippi Medical Centre, Jackson, MS 39216, USA. rhester@umc.edu

The Journal of Physiology

|December 8, 2010

Summary

This summary is machine-generated.

Systems biology integrates medicine and computation to understand complex diseases. Developing a comprehensive human body model is crucial for advancing personalized medicine and improving clinical outcomes.

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Finite Element Modelling of a Cellular Electric Microenvironment

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An Intestine/Liver Microphysiological System for Drug Pharmacokinetic and Toxicological Assessment

An Intestine/Liver Microphysiological System for Drug Pharmacokinetic and Toxicological Assessment

Published on: December 3, 2020

Area of Science:

Systems biology
Translational medicine
Computational biology

Background:

Systems biology integrates biological and medical data with computational approaches.
Genomics and proteomics discoveries drive the need for targeted therapeutic strategies.
Understanding complex disease aetiologies is key for personalized medicine.

Purpose of the Study:

To explore the development of a comprehensive mathematical model of the human body (Human Physiome).
To provide a framework for testing hypotheses in clinical outcomes.
To review current efforts and challenges in creating a validated Human Model.

Main Methods:

Review of existing efforts to develop a Human Physiome.
Discussion of the integration of genetics, proteins, cells, organs, and systems.
Emphasis on mathematical modeling and computational frameworks.

Main Results:

Current data complexity requires systems-level analysis.
A validated Human Model is essential for translational medicine.
Multiple efforts exist to develop a Human Physiome, each with limitations.

Conclusions:

A validated, integrative Human Model is essential for advancing personalized medicine.
Collaborative efforts between integrative physiologists and diverse scientific experts are required.
Accurate human body modeling will facilitate hypothesis testing and improve clinical outcomes.