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Related Concept Videos

The Thyroid Gland01:23

The Thyroid Gland

The thyroid gland is a small, butterfly-shaped gland located in the neck and covers the anterior surface of the trachea. The gland has two lateral lobes connected by a thin tissue mass called the isthmus. Internally, each lobe comprises many small spherical structures known as thyroid follicles, surrounded by a network of blood vessels.
The follicles have a central cavity lined by simple cuboidal to squamous epithelial cells called follicular cells. These cells produce the glycoprotein...
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Hyperthyroidism is a hypermetabolic state caused by elevated levels of thyroid hormones, triiodothyronine (T3) and thyroxine (T4). It results from dysregulation at the thyroid, pituitary, or immune system level and affects multiple organ systems.PathophysiologyThe most common cause of hyperthyroidism is Graves’ disease, an autoimmune disorder in which antibodies, specifically thyroid-stimulating antibodies (TSAb), a subtype of TSH receptor antibodies (TRAb), bind to and activate TSH receptors...

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Computer-Aided Three-Dimensional Visualization in the Treatment of Locally Advanced Thyroid Cancer
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Central compartment dissection in thyroid papillary carcinoma.

Veronique-Isabelle Forest1, Jonathan R Clark, Ardalan Ebrahimi

  • 1Department of Surgery, Sydney Head and Neck Cancer Institute, Royal Prince Alfred Hospital and Sydney University, Sydney, Australia. viforest@yahoo.ca

Annals of Surgery
|December 8, 2010
PubMed
Summary

Elective paratracheal dissection offers minimal benefit for papillary thyroid carcinoma recurrence. Extrathyroidal extension and lymphovascular invasion are key predictors of locoregional recurrence, impacting survival.

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Area of Science:

  • Oncology
  • Surgical Oncology
  • Endocrine Surgery

Background:

  • Systematic elective paratracheal dissection for papillary thyroid carcinoma (PTC) remains a debated surgical approach.
  • Understanding locoregional recurrence patterns is crucial for optimizing PTC management.

Purpose of the Study:

  • To analyze locoregional recurrence (LRR) patterns in PTC patients.
  • To evaluate the potential benefit of elective paratracheal dissection.
  • To identify prognostic factors for locoregional control and disease-specific survival.

Main Methods:

  • Retrospective review of 342 patients with PTC undergoing total thyroidectomy.
  • Analysis of clinicopathological variables associated with survival and recurrence.
  • Assessment of the impact of neck dissection, including paratracheal dissection, on outcomes.

Main Results:

  • Twenty-eight patients (8.2%) developed LRR, with most recurrences in the lateral neck.
  • Extrathyroidal extension (ETE) and lymphovascular invasion were significant independent predictors of LRR.
  • Elective paratracheal dissection did not significantly influence LRR or central compartment control when adjusted for other variables.

Conclusions:

  • The absolute benefit of elective paratracheal dissection in PTC appears small.
  • ETE and lymphovascular invasion are critical prognostic factors for locoregional control and survival in PTC.