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Updated: Jun 6, 2026

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing

Published on: December 11, 2017

Cardiac resynchronization therapy: current trends and future directions.

S Jacob¹, A S Bharadwaj, S S Panaich

¹Division of Cardiology and Electrophysiology, Wayne State University/Detroit Medical Center Detroit, MI 48201, USA. jacobsony@yahoo.com

Minerva Cardioangiologica

|December 8, 2010

Summary

Cardiac resynchronization therapy (CRT) faces challenges in patient selection and management, despite established guidelines. Future research should focus on improving patient selection and developing innovative CRT approaches for better outcomes.

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Area of Science:

Cardiology
Medical Technology

Background:

Cardiac resynchronization therapy (CRT) is indicated for heart failure but has unresolved issues.
High non-response rates necessitate re-evaluation of current CRT practices.

Purpose of the Study:

To review current trends and challenges in cardiac resynchronization therapy (CRT).
To discuss patient selection, procedural aspects, and post-implantation management in CRT.

Main Methods:

Literature review focusing on patient selection criteria, procedural techniques, and management strategies for CRT.
Discussion of QRS duration, imaging for dyssynchrony, and CRT in specific patient groups (asymptomatic, atrial fibrillation).

Main Results:

Patient selection for CRT requires critical appraisal, particularly regarding QRS duration and imaging for ventricular dyssynchrony.
The role of CRT in asymptomatic patients and those with atrial fibrillation remains undefined.
Optimizing surgical techniques, pacing site localization, and programming are crucial for advancing CRT.

Conclusions:

Further research is needed to address controversies in CRT, including developing prediction tools for responders and exploring 'leadless' pacing.
Innovative approaches and goal-directed research are essential to improve CRT efficacy and patient outcomes.