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Updated: Jun 6, 2026
11:14
Detection of Low Copy Number Integrated Viral DNA Formed by In Vitro Hepatitis B Infection
Published on: November 7, 2018
[Chronic hepatitis B with an unexpected coinfection]
Thomas Göbel1, Andreas Erhardt, Joachim Richter
1Klinik für Gastroenterologie, Hepatologie und Infektiologie, Heinrich-Heine Universität Düsseldorf, Düsseldorf, Germany.
Medizinische Klinik (Munich, Germany : 1983)
|December 8, 2010
Summary
Hepatitis B/D coinfection in an African patient unexpectedly revealed Schistosoma mansoni. Early screening for schistosomiasis is crucial in tropical patients with viral hepatitis to avoid overlooked coinfections.
Area of Science:
- Tropical Medicine
- Hepatology
- Infectious Diseases
Background:
- Schistosomiasis and hepatitis B are prevalent tropical diseases with millions infected globally.
- Coinfections are common in endemic areas but rare in Western countries.
- Chronic viral hepatitis patients from tropical regions may have coexisting parasitic infections.
Observation:
- A 34-year-old African patient with known hepatitis B/D coinfection was evaluated for antiviral treatment.
- Liver biopsy revealed a Schistosoma egg granuloma alongside virus-induced liver damage.
- Stool examination confirmed Schistosoma mansoni infection.
Findings:
- Antischistosomal therapy with praziquantel successfully eliminated schistosomiasis.
- This intervention preceded the planned antiviral treatment for hepatitis B/D.
Implications:
- Highlights the importance of screening for neglected tropical diseases like schistosomiasis in patients from endemic areas.
- Underscores the potential for overlooked coinfections in clinical practice.
- Emphasizes the need for specialist evaluation of tropical diseases in patients with chronic viral hepatitis.
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