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Updated: Jun 6, 2026
06:38
An Oncogenic Hepatocyte-Induced Orthotopic Mouse Model of Hepatocellular Cancer Arising in the Setting of Hepatic Inflammation and Fibrosis
Published on: September 12, 2019
Hepatocellular carcinoma with sarcomatous change.
Yosra Said1, Senda Trabelsi, Nadia Kourda
1Department of Gastroenterology and hepatology, Charles Nicolle Hospital, Tunis, Tunisia.
La Tunisie Medicale
|December 8, 2010
Summary
Hepatocellular carcinoma with sarcomatous change is rare and difficult to diagnose. Liver biopsy is essential to distinguish it from ordinary hepatocellular carcinoma (HCC).
Area of Science:
- Hepatology
- Oncology
- Pathology
Background:
- Hepatocellular carcinoma (HCC) with sarcomatous change is a rare malignancy.
- This condition is associated with a poor prognosis.
Observation:
- A 72-year-old male presented with right upper quadrant abdominal pain.
- Imaging revealed a liver mass with atypical enhancement patterns.
- Elevated alpha-fetoprotein levels were noted, but imaging was not typical for HCC.
Findings:
- Percutaneous liver biopsy confirmed hepatocellular carcinoma with sarcomatous change.
- Standard diagnostic methods could not differentiate sarcomatous HCC from ordinary HCC pre-biopsy.
Implications:
- Accurate diagnosis of sarcomatous HCC relies heavily on histopathological examination.
- Further research may be needed to identify specific imaging biomarkers for sarcomatous HCC.
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