Effect of dopamine depletion upon the K(+)-evoked release of CCK from superfused striatal slices
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1Department of Cell and Molecular Biology, Catholic University, Santiago, Chile.
Neuroscience Letters
|May 4, 1990
Abstract:
The effect of a lack of dopamine (DA) in the striatum upon the K(+)-evoked release of cholecystokinin (CCK) from superfused rat striatal slices has been studied. Two pharmacological tools were used to deplete the nigrostriatal DA system: administration of alpha-methyl-p-tyrosine which competitively inhibits DA synthesis and lesions with 6-hydroxydopamine of the medial forebrain bundle. In both cases there was a significant inhibition of the K(+)-evoked release of CCK. The observed effects might be relevant on pathological conditions implying depletion of the DA system.