Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Proteomics01:33

Proteomics

A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term proteomics...
Synthesis and Regulation of Thyroid Hormones01:20

Synthesis and Regulation of Thyroid Hormones

Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The iodine is then...
The Thyroid Gland01:23

The Thyroid Gland

The thyroid gland is a small, butterfly-shaped gland located in the neck and covers the anterior surface of the trachea. The gland has two lateral lobes connected by a thin tissue mass called the isthmus. Internally, each lobe comprises many small spherical structures known as thyroid follicles, surrounded by a network of blood vessels.
The follicles have a central cavity lined by simple cuboidal to squamous epithelial cells called follicular cells. These cells produce the glycoprotein...
Ribosome Profiling02:24

Ribosome Profiling

Ribosome profiling or ribo-sequencing is a deep sequencing technique that produces a snapshot of active translation in a cell. It selectively sequences the mRNAs protected by ribosomes to get an insight into a cell’s translation landscape at any given point in time.
Applications of ribosome profiling
Ribosome profiling has many applications, including in vivo monitoring of translation inside a particular organ or tissue type and quantifying new protein synthesis levels.
The technique helps...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Species-specific regulation of necroptosis by STK38-dependent RIPK1 phosphorylation.

Cell death and differentiation·2026
Same author

Development of novel GPC2-directed radiotheranostics and CAR T cell therapy for neuroblastoma.

Molecular therapy : the journal of the American Society of Gene Therapy·2026
Same author

Ablation of glypican-3 enhances radiosensitivity in liver cancer by prolonging G2/M arrest and activating the ATM/CHK2 pathway.

bioRxiv : the preprint server for biology·2026
Same author

Nuclear Galectin-1 Drives Cancer Progression through <i>O</i>-GlcNAcylation-Dependent Regulation of SOX2.

International journal of biological sciences·2026
Same author

A Novel CD147-Targeting Nanobody for Immuno-PET Imaging of Liver Cancer.

Journal of nuclear medicine : official publication, Society of Nuclear Medicine·2026
Same author

Clinical and Functional Characterization of PDE1A as a Wnt/<b>β</b>-Catenin-Linked Biomarker of Progression and Platinum Resistance in Epithelial Ovarian Cancer.

Oncology research·2026
Same journal

Fecal Proteomics Suggest Potential Biomarkers for Non-Alcoholic Fatty Liver Disease and Steatohepatitis.

Proteomics. Clinical applications·2026
Same journal

An Ensemble Method for Predicting and Designing of Druggable Proteins.

Proteomics. Clinical applications·2026
Same journal

Proteome Profiles of Hypercholesterolemic Patients with and Without FH Treated with a PCSK9 Inhibitor: A Comparison of Depleted and Nondepleted Samples in a Pilot Study.

Proteomics. Clinical applications·2026
Same journal

Proteomic Analysis of Cervicovaginal Fluid for Diagnostic Endometriosis Biomarker Discovery.

Proteomics. Clinical applications·2026
Same journal

Proteomic Analysis of Cerebrospinal Fluid from Severe COVID-19 Patients Reveals Prognostic Biomarkers Associated with Disease Outcome.

Proteomics. Clinical applications·2026
Same journal

A Network-Based Association of IBD and Colorectal Cancer Using Proteomics Data.

Proteomics. Clinical applications·2026
See all related articles

Related Experiment Video

Updated: Jun 6, 2026

Preparation Of Neovascular Tissues from Human Glioma Tissues for Quantitative Proteomics Analysis of Tumor Angiogenesis
09:33

Preparation Of Neovascular Tissues from Human Glioma Tissues for Quantitative Proteomics Analysis of Tumor Angiogenesis

Published on: March 20, 2026

Proteomic expression profiling of thyroid neoplasms.

Till Braunschweig1, Klaus Kaserer, Joon-Yong Chung

  • 1Tissue Array Research Program, Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.

Proteomics. Clinical Applications
|December 8, 2010
PubMed
Summary
This summary is machine-generated.

Identifying new protein biomarkers is crucial for diagnosing thyroid neoplasms. This study found c-erbB-2, Annexin IV, and Stat5a show potential for differentiating common thyroid tumors like follicular adenoma and carcinomas.

More Related Videos

An Ex vivo Culture System to Study Thyroid Development
08:33

An Ex vivo Culture System to Study Thyroid Development

Published on: June 6, 2014

Related Experiment Videos

Last Updated: Jun 6, 2026

Preparation Of Neovascular Tissues from Human Glioma Tissues for Quantitative Proteomics Analysis of Tumor Angiogenesis
09:33

Preparation Of Neovascular Tissues from Human Glioma Tissues for Quantitative Proteomics Analysis of Tumor Angiogenesis

Published on: March 20, 2026

An Ex vivo Culture System to Study Thyroid Development
08:33

An Ex vivo Culture System to Study Thyroid Development

Published on: June 6, 2014

Area of Science:

  • Endocrinology
  • Oncology
  • Proteomics

Background:

  • Thyroid cancer is the most common endocrine neoplasm with diverse subtypes.
  • Distinguishing benign follicular adenomas from malignant follicular and papillary carcinomas presents diagnostic challenges.

Purpose of the Study:

  • To define the proteomic profiles of various thyroid tumors.
  • To identify novel protein biomarkers for improved diagnosis of thyroid neoplasms.

Main Methods:

  • Screened an antibody array with 330 features against five thyroid neoplasms and normal thyroid tissue.
  • Validated eight candidate biomarkers (c-erbB-2, Stat5a, Annexin IV, IL-11, RARα, FGF7, Caspase 9, phospho-c-myc) using immunohistochemistry on 144 tissue microarrays.

Main Results:

  • Eight candidate biomarkers were identified as differentially expressed.
  • c-erbB-2, Annexin IV, and Stat5a demonstrated potential clinical utility in differentiating follicular adenoma, follicular carcinoma, and papillary carcinoma.

Conclusions:

  • An antibody array and tissue microarray approach successfully identified novel diagnostic markers.
  • The identified biomarkers, particularly c-erbB-2, Annexin IV, and Stat5a, show promise for enhancing thyroid neoplasm diagnosis.