Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Microbiota of the Urogenital Tract01:28

Microbiota of the Urogenital Tract

The human urogenital system, once thought to be sterile in healthy individuals, is now recognized as a complex microbial habitat. Advancements in molecular sequencing techniques have revealed that even in healthy adults, the kidneys and bladder harbor microbial populations similar to those found in the distal urethra, albeit in much lower abundance. These resident microorganisms, while generally innocuous, can become opportunistic pathogens under conditions that alter the urogenital...
Proteomics01:33

Proteomics

A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term proteomics...
Urine Studies I: Urinalysis01:29

Urine Studies I: Urinalysis

Urinalysis is a widely used diagnostic test that analyzes urine's physical, chemical, and microscopic characteristics. Healthcare providers use it to detect and monitor various health conditions, including renal disease, urinary tract infections (UTIs), diabetes, and metabolic or systemic disorders.Components of UrinalysisUrinalysis consists of three primary components: physical, chemical, and microscopic examination. Each provides unique insights into the urine sample and, by extension, the...
Urinary Tract Infection III: Diagnostic Studies and Interprofessional Care01:30

Urinary Tract Infection III: Diagnostic Studies and Interprofessional Care

A healthcare provider can diagnose a urinary tract infection (UTI) through several methods:Medical History and Symptoms: The provider will take a detailed medical history and ask about symptoms such as frequent urination, burning sensation during urination, and lower abdominal pain.Urinalysis: A clean-catch urine sample is collected in a sterile container and tested for the presence of bacteria, white blood cells (leukocytes), nitrites, blood, and protein. The presence of leukocytes and...
Physiology of the Genitourinary System III: Urine Concentration and Dilution01:20

Physiology of the Genitourinary System III: Urine Concentration and Dilution

The kidneys concentrate or dilute urine to maintain water and electrolyte balance. Nephrons, particularly the loop of Henle, play a crucial role in this process through the countercurrent multiplication system. This system establishes a high osmolarity in the renal medulla, which is essential for water reabsorption. In the loop of Henle’s descending limb, water is reabsorbed into the surrounding medulla due to its permeability to water. In contrast, the ascending limb actively transports...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Lactobacillus acidophilus abolishes oxalate-mediated renal epithelial barrier disruption and calcium oxalate monohydrate crystal adhesion to renal epithelial cells.

Cellular & molecular biology letters·2026
Same author

Epigallocatechin-3-gallate, L-theanine and theophylline abolish high-glucose-induced renal cell senescence and subsequent epithelial-mesenchymal transition and fibroblast activation via SIRT1/PGC-1α axis: Implications for diabetic kidney disease.

Chemico-biological interactions·2026
Same author

Chlorogenic acid mitigates calcium oxalate monohydrate crystal-induced epithelial-to-mesenchymal transition in renal epithelial cells via suppression of HSP60 expression and p38 signaling.

Cellular & molecular biology letters·2026
Same author

Neutrophil Secretory Proteins Inhibit Calcium Oxalate Crystallisation and Crystal Growth, but Promote Crystal Aggregation.

Immunology·2026
Same author

Promoting Effects of Urinary Proteins from Stone Formers and Influence of Their Physicochemical Properties on Calcium Oxalate Kidney Stone Formation.

Computational and structural biotechnology journal·2026
Same author

Deciphering the impact of <i>SNAI1</i> gene on renal tubular cell proteome, nucleolar stress, ribosome biogenesis, senescence, DNA damage response, and focal adhesion dynamics.

Genes & diseases·2026
Same journal

Fecal Proteomics Suggest Potential Biomarkers for Non-Alcoholic Fatty Liver Disease and Steatohepatitis.

Proteomics. Clinical applications·2026
Same journal

An Ensemble Method for Predicting and Designing of Druggable Proteins.

Proteomics. Clinical applications·2026
Same journal

Proteome Profiles of Hypercholesterolemic Patients with and Without FH Treated with a PCSK9 Inhibitor: A Comparison of Depleted and Nondepleted Samples in a Pilot Study.

Proteomics. Clinical applications·2026
Same journal

Proteomic Analysis of Cervicovaginal Fluid for Diagnostic Endometriosis Biomarker Discovery.

Proteomics. Clinical applications·2026
Same journal

Proteomic Analysis of Cerebrospinal Fluid from Severe COVID-19 Patients Reveals Prognostic Biomarkers Associated with Disease Outcome.

Proteomics. Clinical applications·2026
Same journal

A Network-Based Association of IBD and Colorectal Cancer Using Proteomics Data.

Proteomics. Clinical applications·2026
See all related articles

Related Experiment Video

Updated: Jun 6, 2026

Proteomic Profile of EPS-Urine through FASP Digestion and Data-Independent Analysis
14:48

Proteomic Profile of EPS-Urine through FASP Digestion and Data-Independent Analysis

Published on: May 8, 2021

Recent progress in urinary proteomics.

Visith Thongboonkerd1

  • 1Medical Molecular Biology Unit, Office for Research and Development, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand. thongboonkerd@dr.com, vthongbo@yahoo.com.

Proteomics. Clinical Applications
|December 8, 2010
PubMed
Summary
This summary is machine-generated.

Urinary proteomics offers a noninvasive approach to discover biomarkers for various diseases. This rapidly growing field analyzes urine and other bodily fluids using advanced proteomic technologies.

More Related Videos

A Modified Precipitation Method to Isolate Urinary Exosomes
05:05

A Modified Precipitation Method to Isolate Urinary Exosomes

Published on: January 16, 2015

Related Experiment Videos

Last Updated: Jun 6, 2026

Proteomic Profile of EPS-Urine through FASP Digestion and Data-Independent Analysis
14:48

Proteomic Profile of EPS-Urine through FASP Digestion and Data-Independent Analysis

Published on: May 8, 2021

A Modified Precipitation Method to Isolate Urinary Exosomes
05:05

A Modified Precipitation Method to Isolate Urinary Exosomes

Published on: January 16, 2015

Area of Science:

  • Clinical proteomics
  • Biomarker discovery

Background:

  • Urine is an ideal biofluid for noninvasive biomarker discovery.
  • Urinary proteomics is a rapidly expanding field with significant growth since 2001.

Purpose of the Study:

  • To provide a concise summary of recent applications in urinary proteomics.
  • To discuss proteomic analyses of fluids from renal replacement therapy.

Main Methods:

  • Commonly used techniques include gel-based methods (1-DE, 2-DE, 2-D DIGE).
  • Other applied techniques include LC-MS/MS, SELDI-TOF MS, CE-MS, mass spectrometric immunoassay (MSIA), and array technology.

Main Results:

  • The review summarizes diverse applications of urinary proteomics.
  • Analysis of dialysate and ultrafiltrate fluids from renal replacement therapy is included.

Conclusions:

  • Urinary proteomics is a key area in clinical proteomics for identifying noninvasive disease biomarkers.
  • The field utilizes a range of established and emerging proteomic technologies.