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Related Experiment Video

Updated: Mar 1, 2026

Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice
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Biomarker discovery in glomerular diseases using urinary proteomics.

Visith Thongboonkerd1

  • 1Medical Proteomics Unit and Medical Molecular Biology Unit, Office for Research and Development, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand. thongboonkerd@dr.com, vthongbo@yahoo.com.

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Summary

Urinary proteomics offers a promising, noninvasive approach to discover biomarkers for diagnosing and predicting outcomes in glomerular diseases. This method avoids risks associated with invasive renal biopsies.

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Area of Science:

  • Nephrology
  • Proteomics
  • Biomarker Discovery

Background:

  • Renal biopsy is the gold standard for diagnosing glomerular diseases but carries risks and contraindications.
  • There is a critical need for noninvasive diagnostic and prognostic biomarkers for these kidney conditions.
  • Urine is an ideal source for identifying such biomarkers due to its accessibility.

Purpose of the Study:

  • To review the application of urinary proteomics in identifying biomarkers for various glomerular diseases.
  • To summarize recent findings and discuss the potential of urinary proteome profiling.

Main Methods:

  • Review of studies utilizing proteomic technologies for urinary proteome profiling.
  • Analysis of applications in specific glomerular diseases like diabetic nephropathy, IgA nephropathy, and lupus nephritis.

Main Results:

  • Urinary proteomics has been extensively applied to profile the urine proteome.
  • Numerous studies have explored proteomic biomarkers across a spectrum of glomerular diseases.
  • These investigations highlight the potential of urinary proteomic signatures.

Conclusions:

  • Urinary proteomics shows significant promise for noninvasive biomarker discovery in glomerular diseases.
  • This approach can aid in the diagnosis and prognosis of kidney diseases, offering an alternative to invasive procedures.
  • Continued research in urinary proteome profiling is essential for clinical translation.