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Proteomics

Proteomics

A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term proteomics...

Growth of Cartilage and Bone Tissue

Growth of Cartilage and Bone Tissue

Chondrocytes form a temporary cartilaginous model by dividing and secreting a thick gel-like extracellular matrix. Once the chondrocytes undergo programmed cell death, osteoblasts enter the site of the cartilaginous model. The process of replacing the temporary cartilaginous model with bone in an ordered manner is called endochondral ossification. In endochondral ossification, not all of the cartilage is replaced by bone tissue. Some cartilage that performs a protective and supportive function...

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Related Experiment Video

Updated: Jun 6, 2026

Enrichment of Extracellular Matrix Proteins from Tissues and Digestion into Peptides for Mass Spectrometry Analysis

Enrichment of Extracellular Matrix Proteins from Tissues and Digestion into Peptides for Mass Spectrometry Analysis

Published on: July 23, 2015

Cartilage proteomics: Challenges, solutions and recent advances.

Richard Wilson¹, John F Bateman

¹Murdoch Children's Research Institute, University of Melbourne, Royal Children's Hospital, Parkville, Victoria, Australia.

Proteomics. Clinical Applications

|December 8, 2010

Summary

Proteomic analysis of cartilage extracellular matrix (ECM) is crucial for understanding skeletal development and diseases. This review highlights advancements in characterizing cartilage ECM components and their roles in health and pathology.

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An Ex Vivo Tissue Culture Model of Cartilage Remodeling in Bovine Knee Explants

An Ex Vivo Tissue Culture Model of Cartilage Remodeling in Bovine Knee Explants

Published on: November 3, 2019

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Last Updated: Jun 6, 2026

Enrichment of Extracellular Matrix Proteins from Tissues and Digestion into Peptides for Mass Spectrometry Analysis

Enrichment of Extracellular Matrix Proteins from Tissues and Digestion into Peptides for Mass Spectrometry Analysis

Published on: July 23, 2015

An Ex Vivo Tissue Culture Model of Cartilage Remodeling in Bovine Knee Explants

An Ex Vivo Tissue Culture Model of Cartilage Remodeling in Bovine Knee Explants

Published on: November 3, 2019

Area of Science:

Biochemistry
Biomaterials Science
Orthopedics

Background:

Cartilage, composed of extracellular matrix (ECM) maintained by chondrocytes, provides skeletal structure and joint surfaces.
The cartilage ECM's unique composition is vital for load-bearing and viscoelastic functions.
Disruptions in cartilage ECM components are implicated in numerous skeletal and joint disorders.

Purpose of the Study:

To review the progress in proteomic characterization of cartilage.
To highlight the importance of understanding cartilage ECM in development and disease.

Main Methods:

Proteomic analysis of cartilage and related tissues.
Review of existing literature on cartilage proteome.

Main Results:

Identification of key proteins and proteoglycans within the cartilage ECM.
Understanding the molecular basis of cartilage disorders through proteomic insights.

Conclusions:

Proteomic analysis is an emerging and clinically significant research area for cartilage.
Characterizing the cartilage proteome is essential for diagnosing and potentially treating cartilage-related diseases.