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Related Experiment Video

Updated: Jun 6, 2026

Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice

Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice

Published on: May 2, 2025

Proteomics in diabetic nephropathy.

Hyun-Jung Kim¹, Hyun-Syuk Yoo, Chan-Wha Kim

¹School of Life Sciences and Biotechnology, Korea University, Seoul, Korea.

Proteomics. Clinical Applications

|December 8, 2010

Summary

Proteomics offers a powerful approach to understanding diabetic nephropathy (DN), a major complication of diabetes mellitus (DM). This review highlights how proteomic studies can identify biomarkers and therapeutic targets for DN, aiding clinical applications.

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Last Updated: Jun 6, 2026

Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice

Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice

Published on: May 2, 2025

Area of Science:

Biochemistry
Nephrology
Proteomics

Background:

Diabetes mellitus (DM) is a leading cause of end-stage renal disease (ESRD).
Diabetic nephropathy (DN) affects approximately 40% of diabetic patients.
Understanding DN's complexity requires advanced scientific methods.

Purpose of the Study:

To review the application of proteomics in understanding diabetic nephropathy.
To explore the link between proteomic data and clinical applications for DN.
To summarize recent proteomic studies related to DN.

Main Methods:

Proteomic techniques for exploring DN mechanisms.
Analysis of experimental proteomic data.
Integration of classic physiological and biochemical methods with proteomics.

Main Results:

Proteomics aids in elucidating complex DN mechanisms.
Identification of potential novel biomarkers for DN.
Discovery of new therapeutic targets for DN management.

Conclusions:

Proteomics is a valuable tool for advancing DN research.
Combining proteomics with traditional methods accelerates discoveries in DN.
Translating proteomic findings into clinical practice is crucial for improving patient outcomes.