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Biomarkers in pediatrics: children as biomarker orphans

William J Savage1, Allen D Everett

  • 1Division of Transfusion Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA. Wsavage1@jhmi.edu

Proteomics. Clinical Applications
|December 8, 2010
PubMed

Insights

Biomarker research offers great potential for pediatric patient care, but unique challenges exist in children. This review highlights key considerations and recommendations for advancing pediatric biomarker discovery and validation.

Area of Science:

  • Biomarker research
  • Pediatric medicine
  • Clinical translation

Background:

  • Biomarkers are crucial for diagnosis, prognosis, and treatment monitoring in patient care.
  • Pediatric medicine presents unique challenges and needs for biomarker research.
  • High-quality discovery and validation studies are essential for biomarker translation.

Purpose of the Study:

  • To review the fundamentals of biomarkers.
  • To discuss specific considerations for pediatric biomarker research.
  • To provide recommendations for advancing pediatric biomarker development.

Main Methods:

  • Literature review focusing on biomarker fundamentals.
  • Analysis of challenges and characteristics specific to pediatric medicine.
  • Synthesis of recommendations for pediatric biomarker research.

Main Results:

  • Biomarkers hold significant promise for improving pediatric healthcare outcomes.
  • Translating biomarkers requires rigorous research and validation, with added complexities in pediatrics.
  • Specific adaptations are necessary for pediatric biomarker research.

Conclusions:

  • Addressing pediatric-specific challenges is vital for successful biomarker translation.
  • Recommendations are provided to enhance the development and application of biomarkers in children.
  • Advancing pediatric biomarker research can significantly improve child health.

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