[Age and sex features of antioxidation protection and free-radical processes in white rats brain]

With the years, the activity of antioxidation enzymes and speeds of its free-radical oxidation in different molecules changes. These changes depend also on an animal sex. The brain tissue is especially subjects to oxidising destruction and has the features of antioxidation protection. Level of free-radical processes and activity of basic components of antioxidation link in the different parts of the central nervous system has been investigated. The young animals demonstrated most sex differences in big hemispheres and in intermediate brain, and in a less degree in the middle brain, cerebellum and oblong brain. Sex differences in spinal cord of young animals were not revealed. In aging of animals of different sex, the level of free-radical processes and activity of enzymatic antioxidants changes with unequal speed, and these changes often have an opposite orientation.