Related Experiment Video

Updated: Jun 6, 2026

Evaluation of the Cognitive Performance of Hypertensive Patients with Silent Cerebrovascular Lesions
07:30

Evaluation of the Cognitive Performance of Hypertensive Patients with Silent Cerebrovascular Lesions

Published on: April 23, 2021

[Current problems in mutual relations of cerebral vascular and cardiovascular diseases in elderly and senile age]

T A Borovkova, V S Miakotnykh

    Advances in Gerontology = Uspekhi Gerontologii
    |December 9, 2010
    PubMed

    Insights

    Atherosclerosis is a universal cardiovascular pathology, with aging as its primary driver. Gerontology is key for strategic research, while clinical disciplines focus on diagnostics and treatment of these widespread diseases.

    Area of Science:

    • Cardiovascular Medicine
    • Gerontology
    • Pathology

    Context:

    • Atherosclerosis is a pervasive cardiovascular pathology with complex interrelations across various disease states.
    • The aging process is identified as a critical factor in the development of atherosclerosis, particularly affecting brain and heart vessels.
    • Understanding the universality of atherosclerotic processes is crucial for advancing cardiovascular research.

    Purpose:

    • To explore the multifaceted nature of atherosclerosis as a universal cardiovascular pathology.
    • To examine the intricate relationships between different cardiovascular diseases at clinical, pathogenetic, and biochemical levels.
    • To highlight the role of aging and gerontology in the pathogenesis of atherosclerosis.

    Summary:

    • This research investigates atherosclerosis as a universal pathology, emphasizing the role of aging in its development and impact on cardiovascular and cerebral vessels.
    • The study analyzes the interconnectedness of various cardiovascular diseases, considering their clinical, pathogenetic, pathomorphological, and biochemical aspects.
    • It posits that gerontology is essential for strategic understanding, while clinical specialties like cardiology and neurology are vital for tactical diagnostics and treatment.

    Impact:

    • Provides a unified perspective on cardiovascular diseases driven by atherosclerosis.
    • Underscores the significance of aging as a central factor in cardiovascular health.
    • Delineates the complementary roles of gerontology and clinical disciplines in addressing atherosclerosis.

    More Related Videos

    Using Retinal Imaging to Study Dementia09:17

    Using Retinal Imaging to Study Dementia

    Published on: November 6, 2017

    Isolation and Functional Analysis of Arteriolar Endothelium of Mouse Brain Parenchyma06:40

    Isolation and Functional Analysis of Arteriolar Endothelium of Mouse Brain Parenchyma

    Published on: March 11, 2022

    Related Concept Videos

    Pharmacodynamics in Geriatric Patients: Effects of Age01:27

    Pharmacodynamics in Geriatric Patients: Effects of Age

    Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
    Dementia l: Introduction01:22

    Dementia l: Introduction

    Dementia is an acquired, progressive syndrome characterized by a decline in multiple cognitive domains severe enough to impair daily functioning and reduce independence. Although memory loss is a central feature, the diagnosis requires additional deficits involving language, executive function, visuospatial skills, judgment, calculation, or abstract reasoning. These cognitive impairments reflect underlying neurodegenerative or vascular processes that gradually disrupt neuronal networks...
    Drug Dosing: Geriatric Patients01:15

    Drug Dosing: Geriatric Patients

    Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
    Cerebral Edema ll: Pathophysiology01:22

    Cerebral Edema ll: Pathophysiology

    Vasogenic edema is a major form of cerebral edema characterized by abnormal accumulation of fluid in the brain’s extracellular space due to disruption of the blood–brain barrier (BBB). The BBB is a specialized structure composed of endothelial cells connected by tight junctions, supported by astrocytic endfeet and a basement membrane. Under normal conditions, it tightly regulates the movement of ions, proteins, and solutes between the bloodstream and brain parenchyma. When this barrier loses...
    Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption01:22

    Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption

    As individuals age, their body's physiology evolves, affecting drug pharmacokinetics. The most apparent changes occur in the gastrointestinal tract, where an increase in gastric pH, a delay in gastric emptying, and a reduction in gastrointestinal motility are observed. Remarkably, these changes do not substantially modify the absorption of orally administered drugs, particularly those absorbed via passive diffusion.Transdermal drug delivery emerges as a highly viable method for older adults due...
    Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism01:18

    Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism

    Geriatric patients show significant variation in how their bodies process medications, which can change how effective and safe treatments are. The liver is the primary organ where drug metabolism occurs, involving two main types of chemical reactions: phase I and II. Phase I metabolism is driven by the cytochrome P450 enzyme system, which includes key types such as CYP3A, CYP2D6, and CYP2C9. Research indicates that while aging doesn't notably alter the levels or activity of these enzymes, it...