[Risk factors and long-term results of radiotherapy in grade-3 and -4 brain neoplasms]

Data on the treatment of 278 patients with brain tumors grade III-IV were evaluated, end-results compared and relevant prognostic factors identified. In our view, average fractionated radiotherapy is not inferior to standard fractionation modalities. It offers an advantage of using different single target doses. In primary patients with high-grade malignancies, an index (Karnofsky) of less than 60% appeared to be the most significant practical factor of prognosis. Both age and tumor size proved significant.