Related Experiment Video
Updated: Jun 6, 2026

Self-Nanoemulsification of Healthy Oils to Enhance the Solubility of Lipophilic Drugs
Published on: July 27, 2022
[Prescription design and dissolution evaluation of self-emulsifying drug delivery systems of baicalin]
Xiao-Qin Luo1, Jian-Qiong Yang
1Guangdong Pharmaceutical University, Guangzhou 510006, China. luoxiao-qin@163.com
Objective:
To improve dissolution and bioavailability of baicalin in solid prescription and screen the prescription of self-emulsifying drug delivery systems of baicalin.
Methods:
Orthogonal test was applied to optimize the prescription of self-emulsifying drug delivery systems of baicalin, and the best prescription was selected by comprehensive evaluation of emulsion speed, size and light transmission rate.
Results:
The best quantity ratio of self-emulsifying drug delivery systems of baicalin was baicalin: polysorbate 80: oliver oil: glycerol = 0.15 : 1 : 1 : 1.5.
Conclusion:
Self-emulsifying drug delivery systems of baicalin prepared can effectively improve the dissolution of baicalin in artificial gastric juice.
Related Concept Videos
Bioavailability Enhancement: Drug Solubility Enhancement
Factors Affecting Dissolution: Particle Size and Effective Surface Area
Bioavailability Enhancement: Drug Permeability Enhancement
Bioavailability Enhancement: Drug Stability Enhancement and GI Retention
Factors Influencing Drug Absorption: Drug Dissolution
Drug Dissolution: Requirements and Profile Comparison
