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A New Technique for Quantitative Analysis of Hair Loss in Mice Using Grayscale Analysis
Published on: March 9, 2015
Poorly growing hair in a child
Diana Bolotin1, Bernhard Ortel, Sarah L Stein
1University of Chicago Medical Center, Section of Dermatology, MC5067 5841, South Maryland Avenue, Chicago, IL 60637, USA. dbolotin@uchicago.edu
Insights
Loose anagen syndrome is a hair disorder causing slow hair growth in children. Microscopic examination revealed characteristic findings in anagen hairs, confirming the diagnosis.
Area of Science:
- Pediatric Dermatology
- Trichology
- Genetics
Background:
- Loose anagen syndrome (LAS) is a condition characterized by the premature shedding of anagen hairs.
- It typically presents in childhood with complaints of poor or slow hair growth.
Observation:
- A healthy 5-year-old girl presented with a lifelong history of slow hair growth and fine-textured hair.
- Physical examination revealed short, fine, reddish-blond hair of varying lengths.
- Microscopic examination of plucked hairs showed characteristic features of loose anagen hair, including distorted bulbs and ruffled cuticles.
Findings:
- Hair pull test revealed easily epilated anagen hairs.
- Light microscopy confirmed the presence of loose anagen hairs, diagnostic of loose anagen syndrome.
- No other scalp abnormalities or systemic issues were identified.
Implications:
- This case highlights the importance of microscopic hair examination in diagnosing pediatric hair disorders.
- Early diagnosis of loose anagen syndrome can help manage parental concerns regarding hair growth.
- Further research into the genetic and molecular basis of loose anagen syndrome is warranted.
Abstract:
A healthy 5-year-old Caucasian girl presented to the pediatric dermatology clinic for poor hair growth. The patient's father described slow hair growth and finely textured hair since birth. The patient had her first haircut 1 month before presentation. The family denied bald areas on the scalp, significant hair shedding, and sores on the scalp. The child did not scratch at her scalp or pull her hair. She are a normal diet and had normal growth and development otherwise. She was not taking any medications or over-the-counter supplements. There was no family history of hair disorders. On physical examination, the patient had short, fine, reddish blond hair that was of different lengths (Figure 1). There were no papules, pustules, scale, or crust on her scalp. Lymphadenopathy was absent. She had normal eyelashes and eyebrows. There were no lesions on her oral mucosa. No tooth or nail abnormalities were present. The rest of the physical examination was normal. The hair pull test resulted in 4 easily pulled hairs (3 anagen and 1 telogen). A hair mount was performed (Figure 2). The hair mount analysis revealed anagen hairs with distorted bulbs and ruffled cuticles extending a short distance distally from the bulb, consistent with loose anagen hair (Figure 2). All of the anagen hairs on the pull test demonstrated the above findings. Based on the patient's clinical presentation and the findings seen on light microscopy of the hair mount preparation, the patient was diagnosed with loose anagen syndrome.
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