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Related Experiment Video

Updated: Jun 6, 2026

Myeloid Cell Isolation from Mouse Skin and Draining Lymph Node Following Intradermal Immunization with Live Attenuated Plasmodium Sporozoites

Myeloid Cell Isolation from Mouse Skin and Draining Lymph Node Following Intradermal Immunization with Live Attenuated Plasmodium Sporozoites

Published on: May 18, 2016

Psoriasis triggered by mefloquine.

Joseph L Pace¹

¹University of Malta Medical School, Malta. josephlpace@onvol.net

|December 9, 2010

Summary

Mefloquine, an antimalarial drug, can trigger or worsen psoriasis flare-ups in susceptible individuals. This case highlights the importance of considering drug-induced skin reactions in patients with pre-existing conditions like psoriasis.

Area of Science:

Dermatology
Pharmacology
Tropical Medicine

Background:

Psoriasis is a chronic autoimmune skin condition.
Mefloquine is a widely used antimalarial medication.
Drug-induced exacerbations of psoriasis are a known phenomenon.

Observation:

A 46-year-old man developed a severe psoriasis flare-up shortly after starting mefloquine prophylaxis.
The patient's psoriasis significantly worsened, impacting his hands and feet.
Topical treatments were ineffective, necessitating systemic therapy.

Findings:

The patient experienced a marked deterioration of his psoriasis following mefloquine use.
Initiation of oral methotrexate and continued topical therapy led to significant improvement.

Related Experiment Videos

Last Updated: Jun 6, 2026

Myeloid Cell Isolation from Mouse Skin and Draining Lymph Node Following Intradermal Immunization with Live Attenuated Plasmodium Sporozoites

Myeloid Cell Isolation from Mouse Skin and Draining Lymph Node Following Intradermal Immunization with Live Attenuated Plasmodium Sporozoites

Published on: May 18, 2016

This suggests a potential link between mefloquine and psoriasis exacerbation.

Implications:

Healthcare providers should be aware of mefloquine's potential to trigger or worsen psoriasis.
Patients with a history of psoriasis should be carefully monitored when prescribed mefloquine.
Further research may be warranted to elucidate the mechanisms behind mefloquine-induced psoriasis flares.