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Related Experiment Videos

Cordocentesis for rapid karyotyping.

D M Shah1, P Roussis, J Ulm

  • 1Division of Maternal-Fetal Medicine, Vanderbilt University School of Medicine, Nashville, TN.

American Journal of Obstetrics and Gynecology
|June 1, 1990
PubMed
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Rapid karyotype analysis of fetal blood identified chromosomal abnormalities in 11.9% of fetuses. This diagnostic tool is recommended for pregnancies with structural malformations, growth issues, or hydrops fetalis.

Area of Science:

  • Prenatal Diagnosis
  • Medical Genetics
  • Fetal Medicine

Background:

  • Accurate prenatal diagnosis is crucial for managing fetal conditions.
  • Karyotyping is a standard method for detecting chromosomal abnormalities.

Purpose of the Study:

  • To evaluate the utility of rapid karyotype analysis from fetal blood.
  • To determine the incidence of chromosomal abnormalities in specific high-risk pregnancies.

Main Methods:

  • Obtained pure fetal blood via cordocentesis from 101 fetuses (15-38 weeks gestation).
  • Performed rapid karyotyping using fetal lymphocyte culture, yielding results in 2-4 days.
  • Analyzed karyotype results in relation to various fetal and maternal conditions.

Main Results:

Related Experiment Videos

  • Chromosomal abnormalities were detected in 12 (11.9%) fetuses.
  • Abnormalities were found in fetuses with structural malformations (5/44), intrauterine growth retardation/oligohydramnios (3/13), nonimmune hydrops fetalis (1/3), and discordant twins (2/10).
  • No abnormalities were detected in cases with advanced maternal age or immune thrombocytopenia.

Conclusions:

  • Rapid karyotype analysis is valuable for fetuses with structural malformations, intrauterine growth retardation, and nonimmune hydrops fetalis.
  • Incidental detection of abnormalities is possible in isoimmunized pregnancies and discordant twins.
  • This rapid method aids in timely clinical management decisions for high-risk pregnancies.