Related Experiment Video
Updated: Jun 6, 2026

Measuring Volatile and Non-volatile Antifungal Activity of Biocontrol Products
Published on: December 5, 2020
Antioxidant and antifungal properties of benzimidazole derivatives
Canan Kuş1, Fatma Sözüdönmez, Benay Can-Eke
1Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Ankara University, 06100, Tandogan, Ankara, Turkey. kus@pharmacy.ankara.edu.tr
Abstract:
Antioxidant and radical scavenging properties of a series of 2-[4-(substituted piperazin-/piperidin-1-ylcarbonyl)phenyl]-1H-benzimidazole derivatives were examined. Free radical scavenging properties of compounds 11-30 and 33 were evaluated for the stable free radical 2,2-diphenyl-1-picrylhydrazyl (DPPH) and superoxide anion radical. In addition the inhibitory effects on the NADPH-dependent lipid peroxidation levels were determined by measuring the formation of 2-thiobarbituric acid reactive substances (TBARS) using rat liver microsomes. Compound 33 which has a p-fluorobenzyl substitutent at position 1 exhibited the strongest inhibition (83%) of lipid peroxidation at a concentration of 10(-3) M, while the nonsubstituted analogue 13 caused 57% inhibition. This result is fairly consistent with the antimicrobial activity results against both Staphylococcus aureus and Candida albicans.
More Related Videos
Related Concept Videos
Antifungal Agents
Aryldiazonium Salts to Azo Dyes: Diazo Coupling
Reactions at the Benzylic Position: Oxidation and Reduction
Anthelminthic Agents
Electrophilic Aromatic Substitution: Fluorination and Iodination of Benzene
Antiprotozoal Agents

