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Published on: February 8, 2017
Chronopharmaceutics: as a clinically relevant drug delivery system
B R Gandhi1, A S Mundada, P P Gandhi
1Department of Pharmaceutics, S.S.D.J. College of Pharmacy, Chandwad, 423101 Dist. Nasik, Maharashtra, India.
Drug Delivery
|December 9, 2010
Summary
Researchers are developing advanced drug delivery devices for pulsatile drug release. These systems mimic natural bodily functions, enabling targeted drug delivery with fewer side effects for improved chronotherapy.
Area of Science:
- Pharmacology
- Biomedical Engineering
- Materials Science
Background:
- Many physiological processes rely on pulsatile or transient release of bioactive substances.
- Mimicking these natural rhythms is crucial for effective drug delivery and minimizing side effects.
Purpose of the Study:
- To review various drug delivery systems designed for pulsatile drug release.
- To explore design strategies and stimuli-responsive mechanisms for controlled drug delivery.
Main Methods:
- Review of existing literature on pulsatile drug delivery systems.
- Categorization of systems based on formulation type (reservoir, capsular, osmotic).
- Discussion of stimulus-induced release mechanisms (thermal, electrical, magnetic).
Main Results:
- Several drug delivery systems exhibit pulsatile drug delivery characteristics.
- Design strategies include reservoir, capsular, and osmotic formulations.
- Stimuli-responsive systems offer triggered pulsatile release.
Conclusions:
- Pulsatile drug delivery is a growing area, particularly for chronotherapeutic applications.
- Development of novel drug delivery devices is essential to replicate physiological pulsed release.
- These advanced systems hold promise for enhanced therapeutic efficacy and reduced adverse effects.
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