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Updated: Jun 6, 2026
06:47
Microfluidics in Assessing Platelet Function
Published on: November 8, 2024
Ticagrelor: a novel oral antiplatelet agent
Nina S Huang1, Huzefa H Master, Julie A Fusco
1Midwestern University Chicago College of Pharmacy, Downers Grove, IL, USA.
Summary
Ticagrelor, a reversible P2Y12 antagonist, shows promise in reducing cardiovascular death compared to clopidogrel. However, its use in the elderly requires careful consideration due to increased bleeding risks.
Area of Science:
- Cardiovascular Pharmacology
- Antiplatelet Therapy
Background:
- Ticagrelor represents a novel class of reversible oral P2Y12 receptor antagonists.
- Understanding its pharmacological profile is crucial for optimizing antiplatelet strategies.
Purpose of the Study:
- To review the pharmacology, clinical efficacy, and tolerability of ticagrelor.
- To discuss the implications of ticagrelor use in the elderly population.
Main Methods:
- Literature search of MEDLINE (1966-2010) using terms related to ticagrelor and P2Y12 antagonists.
- Review of randomized controlled trials and relevant pharmacodynamic/pharmacokinetic studies.
Main Results:
- Ticagrelor offers faster onset, offset, and reversibility compared to clopidogrel.
- The Study of Platelet Inhibition and Patient Outcomes trial showed ticagrelor reduced cardiovascular death without increasing major or CABG-related bleeding.
- Elderly patients may benefit, but increased non-CABG bleeding and unique adverse events warrant caution.
Conclusions:
- Ticagrelor's use in elderly patients necessitates individualized assessment.
- Further research is required to establish definitive therapeutic guidelines for ticagrelor in the elderly.
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