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Updated: Jun 6, 2026
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Monitoring Hippo Signaling Pathway Activity Using a Luciferase-based Large Tumor Suppressor (LATS) Biosensor
Published on: September 13, 2018
Hippo signaling: growth control and beyond
Georg Halder1, Randy L Johnson
1Department of Biochemistry and Molecular Biology, MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA. ghalder@mdanderson.org
Development (Cambridge, England)
|December 9, 2010
Summary
The Hippo pathway regulates organ growth. Recent discoveries reveal new upstream inputs and downstream effects, advancing understanding of its role in development and regeneration.
Area of Science:
- Developmental Biology
- Cell Signaling
- Molecular Biology
Background:
- The Hippo pathway is crucial for organ size control in Drosophila and vertebrates.
- Core kinase mechanisms (Hippo/Mst, Warts/Lats) are understood, but upstream regulation and downstream outputs are less clear.
Purpose of the Study:
- To review recent advances in understanding Hippo pathway regulation.
- To discuss the diverse developmental functions of Hippo signaling.
Main Methods:
- Literature review of recent studies on Hippo pathway mechanisms.
- Analysis of dynamic regulation during development in model organisms.
Main Results:
- New mechanisms for dynamic Hippo signaling regulation have been identified.
- The diversity of Hippo pathway functions in development is expanding.
Conclusions:
- Recent discoveries illuminate the complex regulatory system of the Hippo pathway.
- New insights into organ growth and regeneration mechanisms are emerging.
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