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Laparoscopic S7 Hepatectomy with Positive Fluorescence Staining
Published on: May 9, 2025
Carcinosarcoma of the liver
Hideaki Goto1, Atsushi Tanaka, Fukuo Kondo
1Department of Medicine, Teikyo University School of Medicine, Tokyo.
Internal Medicine (Tokyo, Japan)
|December 9, 2010
Summary
This case study describes a rare primary liver carcinosarcoma in a patient with HBV-related cirrhosis. The tumor exhibited diverse cell types, including hepatocellular carcinoma and sarcoma components.
Area of Science:
- Hepatology
- Oncology
- Pathology
Background:
- Presents a rare case of primary carcinosarcoma of the liver.
- Patient had a history of HBV-related liver cirrhosis, necessitating regular follow-up.
- Ultrasound revealed a hyperechoic liver tumor, leading to further investigation.
Observation:
- Dynamic CT showed a hypoenhancing hepatic mass with peripheral ring enhancement.
- Surgical resection revealed a 3 cm nodular tumor with a fibrous capsule.
- Microscopic examination identified dominant undifferentiated cells, moderately differentiated hepatocellular carcinoma (HCC), and transitional zones.
Findings:
- Tumor tissue also contained adenocarcinoma, osteosarcoma, and chondrosarcoma components.
- Immunohistochemistry confirmed HepPar 1 positivity in HCC, CK19/CK7 in adenocarcinoma.
- Undifferentiated cells showed occasional positivity for CD56, chromogranin A, and c-kit.
Implications:
- Definitive diagnosis of carcinosarcoma based on concurrent HCC and sarcomatous elements.
- Highlights the complex cellular heterogeneity observed in this rare liver malignancy.
- Emphasizes the importance of comprehensive histopathological and immunohistochemical analysis for accurate diagnosis.