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Experience with ofloxacin in enteric fever
1Department of Medicine, Ain-Shams University, Cairo, Egypt.
Journal of Chemotherapy (Florence, Italy)
|April 1, 1990
Summary
Ofloxacin effectively treated 28 patients with enteric fever, achieving clinical and bacteriological cures. Patients experienced rapid fever reduction and no relapses during a 12-week follow-up, highlighting ofloxacin
Area of Science:
- Infectious Diseases
- Microbiology
- Pharmacology
Background:
- Enteric fever, a serious bacterial infection, poses a significant global health challenge.
- Antibiotic resistance necessitates the evaluation of effective treatment options for enteric fever.
Purpose of the Study:
- To assess the efficacy and safety of ofloxacin in treating patients diagnosed with enteric fever.
- To determine the clinical and bacteriological cure rates and relapse incidence of ofloxacin therapy.
Main Methods:
- A study involving 28 patients diagnosed with enteric fever and confirmed by positive blood cultures.
- Treatment administered: Ofloxacin 200 mg twice daily for 8 days.
- Clinical and bacteriological assessments were conducted throughout the treatment and a 12-week follow-up period.
Main Results:
- All 28 patients achieved complete clinical and bacteriological cure.
- Mean fever resolution time was 3.1 days (range 1.6-5.3 days).
- No clinical or bacteriological relapses were observed during the 12-week follow-up.
Conclusions:
- Ofloxacin is a highly effective antibiotic for treating enteric fever.
- The treatment regimen demonstrated rapid symptomatic relief and sustained eradication of the infection.
- Ofloxacin offers a safe and reliable therapeutic option for enteric fever, with no observed relapses.