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Updated: Feb 12, 2026

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MicroRNA-21: a novel therapeutic target in human cancer

Xuan Pan1, Zhao-Xia Wang, Rui Wang

  • 1The Second Affiliated Hospital of Nanjing Medical University, Nanjing, China.

Cancer Biology & Therapy
|December 9, 2010
PubMed

Insights

MicroRNAs (miRNAs) are key regulators in cancer. This review details how miR-21 contributes to anticancer drug resistance and explores its potential as a therapeutic target.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Anticancer drug resistance is a significant challenge in cancer treatment.
  • MicroRNAs (miRNAs) are small noncoding RNAs regulating gene expression and are implicated in cancer.
  • miR-21 is frequently overexpressed in tumors and functions as an oncogene.

Purpose of the Study:

  • To review the mechanisms of miR-21-mediated chemoresistance.
  • To discuss the potential of miR-21 as a target for cancer therapy.

Main Methods:

  • Literature review of studies on miR-21 and chemoresistance.
  • Analysis of in vivo and in vitro experimental data.

Main Results:

  • miR-21 overexpression is linked to resistance against various anticancer drugs.
  • miR-21 targets tumor suppressor genes involved in drug response pathways.
  • miR-21 has shown potential as a diagnostic and prognostic marker.

Conclusions:

  • miR-21 plays a critical role in the development of chemoresistance.
  • Targeting miR-21 may offer a novel strategy to overcome drug resistance in cancer treatment.

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