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Updated: Jun 6, 2026

Interventional Diagnostic Procedure: A Practical Guide for the Assessment of Coronary Vascular Function

Interventional Diagnostic Procedure: A Practical Guide for the Assessment of Coronary Vascular Function

Published on: March 15, 2022

Percutaneous coronary intervention in the elderly.

Tracy Y Wang¹, Antonio Gutierrez, Eric D Peterson

¹Duke Clinical Research Institute, 2400 Pratt Street, Durham, NC 27705, USA.

Nature Reviews. Cardiology

|December 9, 2010

Summary

This summary is machine-generated.

Percutaneous coronary intervention (PCI) offers significant benefits for elderly patients with ischemic heart disease. Optimizing PCI outcomes in older adults requires individualized care, addressing bleeding risks, and careful medication management.

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Last Updated: Jun 6, 2026

Interventional Diagnostic Procedure: A Practical Guide for the Assessment of Coronary Vascular Function

Interventional Diagnostic Procedure: A Practical Guide for the Assessment of Coronary Vascular Function

Published on: March 15, 2022

Area of Science:

Cardiovascular Medicine
Interventional Cardiology
Geriatric Cardiology

Background:

Growing proportion of elderly patients (≥75 years) undergoing percutaneous coronary intervention (PCI).
Elderly patients have higher cardiovascular risk and ischemic disease burden, yet face increased procedural complication risks.
Age-related physiological changes, frailty, and comorbidities contribute to increased risks in older adults.

Purpose of the Study:

To review revascularization outcomes in elderly patients undergoing PCI.
To assess the impact of advancements in PCI techniques and pharmacotherapy on elderly patient outcomes.
To address current clinical challenges and identify future research needs for optimizing PCI in this population.

Main Methods:

Review of contemporary practices and outcomes of percutaneous coronary intervention in patients aged ≥75 years.
Analysis of the influence of evolving PCI techniques and adjuvant pharmacotherapy on treatment efficacy and safety.
Discussion of clinical decision-making processes, risk factor management, and therapeutic strategies for elderly PCI candidates.

Main Results:

Elderly patients derive substantial benefit from PCI due to greater ischemic disease burden.
Advancements in PCI techniques and pharmacotherapy have improved outcomes but challenges remain.
Increased risk of procedural complications is associated with age-related factors and comorbidities.

Conclusions:

Maximizing PCI benefits in the elderly necessitates explicit patient-provider discussions on treatment goals.
Individualized care, including managing bleeding risks and optimizing medical therapy timing and dosing, is crucial.
Further research is needed to refine PCI strategies and improve long-term outcomes for older adults.