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Murine Oropharyngeal Aspiration Model of Ventilator-associated and Hospital-acquired Bacterial Pneumonia
04:32

Murine Oropharyngeal Aspiration Model of Ventilator-associated and Hospital-acquired Bacterial Pneumonia

Published on: June 28, 2018

Multi-drug resistant Acinetobacter ventilator-associated pneumonia

Vishal B Shete1, Dnyaneshwari P Ghadage, Vrishali A Muley

  • 1Department of Microbiology, BJ Medical College and Sassoon General Hospital, Pune, India.

Lung India : Official Organ of Indian Chest Society
|December 9, 2010
PubMed
Abstract

Insights

Multi-drug resistant Acinetobacter causes ventilator-associated pneumonia (VAP) in ICUs. This study found an 11.6% incidence of Acinetobacter VAP, linked to head injuries, cerebral hemorrhage, and COPD, highlighting the need for strict infection control.

Area of Science:

  • Critical care medicine
  • Infectious diseases
  • Microbiology

Background:

  • Ventilator-associated pneumonia (VAP) caused by multidrug-resistant (MDR) Acinetobacter is a significant challenge in intensive care units (ICUs).
  • Acinetobacter infections in VAP cases require thorough investigation due to their severity and resistance patterns.

Purpose of the Study:

  • To determine the incidence of Acinetobacter infection in VAP cases.
  • To identify risk factors associated with Acinetobacter acquisition in VAP patients.
  • To analyze the antimicrobial susceptibility patterns of Acinetobacter strains.

Main Methods:

  • Bacteriological analysis of 60 endotracheal aspirate specimens from intubated patients diagnosed with VAP.
  • Collection of clinical details and antibiotic exposure history for all patients.

Main Results:

  • An incidence of 11.6% for Acinetobacter VAP was recorded.
  • Underlying conditions such as head injury, cerebral hemorrhage, and chronic obstructive pulmonary disease (COPD) were associated with Acinetobacter VAP.
  • Acinetobacter strains demonstrated a multidrug-resistant (MDR) pattern.

Conclusions:

  • Strict infection control measures are crucial for managing Acinetobacter VAP.
  • Judicious antibiotic prescribing, resistance surveillance, and antibiotic cycling are recommended strategies.
  • Implementing these measures can help control Acinetobacter infections in ICU patients.
Keywords:
Acinetobactermulti-drug resistanceventilator-associated pneumonia

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