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Tumorsphere Derivation and Treatment from Primary Tumor Cells Isolated from Mouse Rhabdomyosarcomas
Published on: September 13, 2019
Rare tumors research in emerging countries
Max S Mano1, Roberto J Arai, Paulo M G Hoff
1Instituto do Câncer do Estado de São Paulo (ICESP), Faculdade de Medicine da Universidade de São Paulo (FMUSP), Brazil.
Abstract:
Rare tumors, when considered as a group, represent a significant burden to society as they may account for up to 25% of the mortality by cancer in nations like the United States. In contrast with the current scenario in highly incident cancer types, little progress has been achieved in the treatment of the most rare cancers. The reasons for this apparent stagnation are mostly intrinsic to logistical difficulties in performing large clinical trials in rare diseases and will be addressed further in this article. Because both cancer incidence and clinical research are booming in emerging nations, we also aim to address the current and future role of these countries in research and the drug development process in rare tumor types.
Insights
Rare tumors cause significant cancer mortality, yet treatment advances lag due to clinical trial challenges. This article explores these difficulties and the growing role of emerging nations in rare cancer research and drug development.
Area of Science:
- Oncology
- Clinical Research
- Global Health
Background:
- Rare tumors collectively contribute significantly to cancer mortality, particularly in developed nations.
- Treatment progress for rare cancers lags considerably behind that of common cancer types.
- Logistical challenges in conducting large-scale clinical trials impede rare cancer research.
Purpose of the Study:
- To examine the reasons behind the stagnation in rare cancer treatment.
- To explore the current and future role of emerging nations in rare tumor research.
- To discuss the drug development process for rare tumor types.
Main Methods:
- Literature review and analysis of clinical trial challenges in rare diseases.
- Examination of cancer incidence and research trends in emerging economies.
- Discussion of drug development pathways for rare tumors.
Main Results:
- Significant mortality burden from rare tumors, up to 25% in some nations.
- Limited progress in rare cancer treatment due to inherent research difficulties.
- Emerging nations show increasing potential in cancer research and drug development.
Conclusions:
- Addressing logistical hurdles in clinical trials is crucial for advancing rare cancer care.
- Emerging nations are poised to play an increasingly vital role in rare tumor research and therapeutic development.
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