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Updated: Jun 6, 2026

Mouse Model of Acute to Chronic Kidney Disease Transition Induced by Renal Ischemia/Reperfusion Injury
Published on: February 10, 2026
Nephrotoxicity of contrast media and protective effects of acetylcysteine
Carlo Briguori1, Cristina Quintavalle, Francesca De Micco
1Clinica Mediterranea, Laboratory of Interventional Cardiology, Naples, Italy. carlobriguori@clinicamediterranea.it
Abstract:
Contrast-induced acute kidney injury (CI-AKI) accounts for approximately 10% of all causes of hospital-acquired renal failure, causes a prolonged in-hospital stay, and represents a powerful predictor of poor early and late outcome. N-acetylcysteine (NAC) is a thiol compound classically known as a mucolytic agent, which is a potent antioxidant that scavenges a wide variety of oxygen-derived-free-radicals and may be capable of preventing acute kidney injury. In the present study, we will review (1) the pathophysiology of the CI-AKI and (2) the experimental and clinical data on the effects of NAC in preventing CI-AKI.
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