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TP53 codon 72 polymorphism and colorectal cancer susceptibility: a meta-analysis
Jing-Jun Wang1, Yuan Zheng, Liang Sun
1Department of Center for Disease Control and Prevention of Shaanxi Province, 3 Jiandong Road, 710043 Xi'an, Shaanxi, People's Republic of China.
Molecular Biology Reports
|December 9, 2010
Summary
This meta-analysis found no association between TP53 codon 72 polymorphism and colorectal cancer risk. The study suggests limited biological usefulness of this genetic marker for predicting colorectal cancer susceptibility.
Area of Science:
- Genetics
- Oncology
- Molecular Biology
Background:
- Colorectal cancer (CRC) is a major global health concern.
- The TP53 codon 72 polymorphism has been investigated for its potential link to CRC susceptibility.
- Previous studies yielded conflicting results regarding this association.
Purpose of the Study:
- To systematically evaluate the association between TP53 codon 72 polymorphism and colorectal cancer risk.
- To provide a more precise estimation of the relationship by pooling data from multiple studies.
Main Methods:
- A systematic literature search was conducted in Medline, Google Scholar, and Ovid databases for studies published before May 2010.
- Meta-analysis was performed on data including 3603 colorectal cancer cases and 5524 controls.
- Subgroup analyses were performed based on ethnic groups and control sources.
Main Results:
- No significant association was found between TP53 codon 72 polymorphism and colorectal cancer risk across all genetic models (dominant, recessive, Arg/Pro vs. Arg/Arg, Pro/Pro vs. Arg/Arg).
- Odds ratios (OR) and 95% confidence intervals (CI) indicated no increased risk (e.g., dominant model: OR = 0.99, 95% CI: 0.86-1.15).
- Subgroup analyses by ethnicity and control source also revealed no significant associations.
Conclusions:
- The TP53 codon 72 polymorphism is not significantly associated with colorectal cancer susceptibility.
- The biological utility of TP53 codon 72 polymorphism as a selection marker for colorectal cancer risk is likely very limited.
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