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Insulin resistance is associated with at least threefold increased risk for prothrombotic state in severely obese

Assimina Galli-Tsinopoulou1, Ioannis Kyrgios, Ioanna Maggana

  • 14th Department of Pediatrics, Medical School, Aristotle University of Thessaloniki, Papageorgiou General Hospital, Thessaloniki, Greece. gallitsin@gmail.com

European Journal of Pediatrics
|December 9, 2010
PubMed

Insights

Childhood obesity with insulin resistance significantly elevates prothrombotic factors, increasing the risk of early cardiovascular disease. This finding highlights the link between metabolic health in youth and adult cardiovascular outcomes.

Area of Science:

  • Pediatric Endocrinology
  • Cardiovascular Health
  • Thrombosis Research

Background:

  • Childhood obesity is a growing concern linked to future cardiovascular disease.
  • The specific mechanisms connecting childhood obesity to cardiovascular risk remain incompletely understood.
  • Prothrombotic factors play a crucial role in the development of cardiovascular and thrombotic events.

Purpose of the Study:

  • To measure prothrombotic factor levels in obese children and adolescents.
  • To investigate the association between obesity, insulin resistance, and prothrombotic factors.
  • To explore the implications for early cardiovascular disease risk.

Main Methods:

  • Cross-sectional study of 313 obese children and adolescents.
  • Measurement of anthropometric parameters, prothrombotic factors (PAI-1-Ag, vWF-Ag, fibrinogen), lipids, glucose, and insulin.
  • Assessment of insulin resistance using the Homeostasis Model Assessment for Insulin Resistance (HOMA-IR) index.

Main Results:

  • Insulin-resistant participants showed significantly higher levels of PAI-1-Ag and vWF-Ag.
  • Elevated PAI-1-Ag and vWF-Ag levels were associated with a 3-5 fold increased risk in insulin-resistant individuals.
  • Prothrombotic factors (PAI-1-Ag, vWF-Ag) correlated positively with BMI, insulin levels, and HOMA-IR.

Conclusions:

  • Obesity combined with insulin resistance in youth is linked to elevated prothrombotic factors.
  • This prothrombotic state may contribute to the early development of atherothrombosis.
  • These findings suggest a mechanism for increased cardiovascular disease risk in adulthood.
Abstract

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