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Related Concept Videos

Glaucoma: Overview01:25

Glaucoma: Overview

Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
Open Angle Glaucoma: Treatment01:27

Open Angle Glaucoma: Treatment

In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
Angle Closure Glaucoma: Treatment01:28

Angle Closure Glaucoma: Treatment

Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
Gastritis II: Pathophysiology01:26

Gastritis II: Pathophysiology

The pathophysiology of gastritis begins with the colonization of the stomach lining by Helicobacter pylori (H. pylori). This bacterium spreads mainly via the oral-oral route through saliva or shared utensils, and can also be transmitted in overcrowded or unhygienic environments through contaminated water, despite its brief survival outside the body.ColonizationOnce ingested, H. pylori enters the stomach and begins colonization by navigating through the mucus layer lining the stomach wall. It...
Peptic Ulcer01:27

Peptic Ulcer

Peptic ulcers are erosive lesions of the gastric or duodenal lining, most commonly caused by Helicobacter pylori infection. This Gram-negative, helical bacterium has adapted to survive the stomach’s acidic environment by producing urease, which converts urea into ammonia and carbon dioxide. The ammonia neutralizes gastric acid in the bacterium’s immediate environment, allowing colonization of the gastric mucosa. H. pylori attaches to mucus-secreting epithelial cells, penetrates the mucus...
Peptic Ulcer Disease II: Pathophysiology01:24

Peptic Ulcer Disease II: Pathophysiology

Peptic ulcer disease develops when protective mechanisms of the gastrointestinal mucosa are overwhelmed by harmful factors, leading to localized erosions in the stomach or proximal duodenum. The main causes are Helicobacter pylori infection and chronic use of nonsteroidal anti-inflammatory drugs (NSAIDs).Helicobacter pylori–Induced InjuryBacterial Adaptation and Colonization:H. pylori is a spiral, Gram-negative bacterium adapted to the acidic stomach. and transmitted through oral-oral or...

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Related Experiment Video

Updated: Jun 6, 2026

Laser Capture Microdissection of Highly Pure Trabecular Meshwork from Mouse Eyes for Gene Expression Analysis
13:47

Laser Capture Microdissection of Highly Pure Trabecular Meshwork from Mouse Eyes for Gene Expression Analysis

Published on: June 3, 2018

Association between helicobacter pylori and open angle glaucoma: current perspective.

M Zaidi1, F A Jilani, Y Gupta

  • 1Institute of Ophthalmology, Aligarh Muslim University, Aligarh-202002; India. meenazaidi@rediffmail.com

Nepalese Journal of Ophthalmology : a Biannual Peer-Reviewed Academic Journal of the Nepal Ophthalmic Society : NEPJOPH
|December 15, 2010
PubMed
Summary

Helicobacter pylori (H. pylori) infection generates free radicals and may worsen glaucoma by increasing nitric oxide and endothelin-1. This review explores the potential link between H. pylori and glaucoma progression.

Related Experiment Videos

Last Updated: Jun 6, 2026

Laser Capture Microdissection of Highly Pure Trabecular Meshwork from Mouse Eyes for Gene Expression Analysis
13:47

Laser Capture Microdissection of Highly Pure Trabecular Meshwork from Mouse Eyes for Gene Expression Analysis

Published on: June 3, 2018

Area of Science:

  • Microbiology
  • Ophthalmology
  • Pathogen Research

Background:

  • Helicobacter pylori is a Gram-negative, micro-aerophilic bacterium colonizing the stomach.
  • H. pylori infection is associated with increased production of oxygen free radicals.
  • Emerging evidence suggests a potential indirect link between H. pylori and glaucoma.

Purpose of the Study:

  • To review current perspectives on the potential role of Helicobacter pylori infection in the pathogenesis or progression of glaucoma.
  • To explore the mechanisms by which H. pylori might influence ocular health.

Main Methods:

  • Literature review of existing studies on H. pylori infection.
  • Analysis of proposed mechanisms linking bacterial infection to glaucoma.
  • Synthesis of current research on oxidative stress and nitric oxide in both H. pylori and glaucoma.

Main Results:

  • H. pylori infection induces oxidative stress through free radical generation.
  • Increased levels of nitric oxide and endothelin-1 are implicated in glaucoma.
  • H. pylori may indirectly elevate these factors, potentially exacerbating glaucoma.

Conclusions:

  • Helicobacter pylori infection presents a potential, albeit indirect, risk factor for glaucoma aggravation.
  • Further research is warranted to elucidate the precise mechanisms and clinical significance of this association.
  • Understanding this link may offer novel therapeutic targets for glaucoma management.