Related Experiment Video

Updated: Jun 6, 2026

High Resolution Electron Microscopy of the Helicobacter pylori Cag Type IV Secretion System Pili Produced in Varying Conditions of Iron Availability
09:05

High Resolution Electron Microscopy of the Helicobacter pylori Cag Type IV Secretion System Pili Produced in Varying Conditions of Iron Availability

Published on: November 21, 2014

Helicobacter pylori infection among a pediatric population with sickle cell disease

Idowu Senbanjo1, Akinsegun Akinbami, Ijeoma Diaku-Akinwumi

  • 1Paediatrics Gastroenterology, Hepatology and Nutrition Unit, Department of Paediatrics and Child Health, Lagos State University College of Medicine, PMB 21266, Ikeja, Lagos, Nigeria. senbanjo001@yahoo.com

Journal of the National Medical Association
|December 15, 2010
PubMed

Insights

Helicobacter pylori infection is common in children with sickle cell disease (SCD) and their peers in Nigeria. However, H. pylori infection was not significantly linked to recurrent abdominal pain in SCD children.

Area of Science:

  • Pediatric Gastroenterology
  • Infectious Diseases
  • Hematology

Background:

  • Recurrent abdominal pain (RAP) is a frequent symptom in children with sickle cell disease (SCD).
  • Potential causes of RAP in SCD children include disease complications, surgical issues, and Helicobacter pylori (H. pylori) gastritis.
  • The prevalence of H. pylori infection in SCD children remains unestablished.

Purpose of the Study:

  • To determine the prevalence of H. pylori infection in children with SCD.
  • To investigate the association between H. pylori infection and RAP in children with SCD.

Main Methods:

  • A prospective case-control study was conducted involving 118 SCD children and 118 matched non-SCD children.
  • H. pylori infection seroprevalence was assessed using enzyme-linked immunosorbent assay (ELISA) for immunoglobulin G antibodies.
  • Participants were recruited from Lagos State University Teaching Hospital, Nigeria.

Main Results:

  • The overall prevalence of H. pylori infection was high in both groups (SCD: 67.8%; non-SCD: 63.6%).
  • H. pylori infection prevalence increased with age, peaking between 6 and 10 years old.
  • H. pylori infection was significantly associated with parental socioeconomic status but not with RAP in SCD children.

Conclusions:

  • H. pylori infection is highly prevalent in both SCD and non-SCD children in the studied Nigerian population.
  • No significant association was found between H. pylori infection and recurrent abdominal pain in children with sickle cell disease.
Abstract

More Related Videos

Gastric Mucosa Quantitative Polymerase Chain Reaction Analysis for Detecting Helicobacter pylori and Antibiotic Resistance05:23

Gastric Mucosa Quantitative Polymerase Chain Reaction Analysis for Detecting Helicobacter pylori and Antibiotic Resistance

Published on: March 7, 2025

Related Concept Videos

Peptic Ulcer01:27

Peptic Ulcer

Peptic ulcers are erosive lesions of the gastric or duodenal lining, most commonly caused by Helicobacter pylori infection. This Gram-negative, helical bacterium has adapted to survive the stomach’s acidic environment by producing urease, which converts urea into ammonia and carbon dioxide. The ammonia neutralizes gastric acid in the bacterium’s immediate environment, allowing colonization of the gastric mucosa. H. pylori attaches to mucus-secreting epithelial cells, penetrates the mucus...
Gastritis II: Pathophysiology01:26

Gastritis II: Pathophysiology

The pathophysiology of gastritis begins with the colonization of the stomach lining by Helicobacter pylori (H. pylori). This bacterium spreads mainly via the oral-oral route through saliva or shared utensils, and can also be transmitted in overcrowded or unhygienic environments through contaminated water, despite its brief survival outside the body.ColonizationOnce ingested, H. pylori enters the stomach and begins colonization by navigating through the mucus layer lining the stomach wall. It...
Treating Helicobacter pylori in Peptic Ulcers: Antimicrobial Therapy01:16

Treating Helicobacter pylori in Peptic Ulcers: Antimicrobial Therapy

Helicobacter pylori, a resilient gram-negative bacterium, can thrive in the stomach's harsh, acidic environment. Infection with H. pylori leads to a cascade of events within the stomach lining. One of the critical disruptions caused by this bacterium is the interference with somatostatin production, a hormone responsible for regulating acid secretion. This interference tips the balance, escalating acid secretion and diminishing bicarbonate levels. This imbalance compromises the defensive...
Peptic Ulcer Disease I: Introduction01:30

Peptic Ulcer Disease I: Introduction

Peptic Ulcer Disease (PUD) is characterized by mucosal excavation in the esophagus, stomach, pylorus, or duodenum. It can manifest as acute or chronic based on the extent and duration of mucosal involvement.
An acute ulcer, marked by superficial erosion and minimal inflammation, swiftly resolves upon identifying and addressing the underlying cause. In contrast, a chronic ulcer persists, potentially eroding through the muscular wall and forming fibrous tissue.
Peptic ulcers can also be...
Peptic Ulcer Disease I: Introduction01:25

Peptic Ulcer Disease I: Introduction

Peptic ulcer disease (PUD) involves breaks in the gastrointestinal tract's mucosal lining, primarily in the stomach and duodenum, with less frequent occurrences in the lower esophagus or near the pylorus.Ulcers can be acute or chronic. Acute ulcers are short-lived with minimal inflammation and heal quickly after the irritant is removed. Chronic ulcers persist, may recur, and often cause scarring due to ongoing tissue damage. Superficial erosions affect only the mucosal layer and are called...
Peptic Ulcer Disease III: Clinical Manifestations and Diagnostic Studies01:28

Peptic Ulcer Disease III: Clinical Manifestations and Diagnostic Studies

Peptic ulcer disease (PUD) presents with diverse symptoms depending on the location and severity of the ulcer. Clinical manifestations of peptic ulcer include dull pain and a burning sensation in the mid-epigastric region.
Few clinical manifestations differentiate gastric ulcers from duodenal ulcers. Distinctions in the location, timing, and pain relief are crucial for healthcare providers in differentiating between gastric and duodenal ulcers during clinical assessments.