Related Experiment Video
Updated: Jun 6, 2026

Investigating the Pathogenesis of MYH7 Mutation Gly823Glu in Familial Hypertrophic Cardiomyopathy using a Mouse Model
Published on: August 8, 2022
Cause of heart murmurs in 57 apparently healthy cats
M J M Dirven1, J M M Cornelissen, M A M Barendse
1Dierenkliniek Rijen, Rijen, The Netherlands. mark.dirven@dierenkliniekrijen.nl
Insights
In apparently healthy cats, heart murmurs often indicate underlying heart disease, frequently caused by dynamic outflow tract obstruction. Echocardiography is recommended to diagnose the cause of murmurs and confirm heart disease.
Area of Science:
- Veterinary Cardiology
- Cardiac Auscultation
- Echocardiography
Background:
- Heart murmurs arise from turbulent blood flow or cardiac structure vibrations.
- Causes include structural heart disease or physiological factors.
- Identifying murmur origins in healthy cats is crucial for disease detection.
Purpose of the Study:
- To determine the cause of heart murmurs in apparently healthy adult cats.
- To assess if heart murmurs reliably indicate heart disease in cats.
- To correlate auscultation findings with echocardiographic results.
Main Methods:
- Retrospective review of medical records from January 2008 to December 2009.
- Inclusion of cats with murmurs detected during physical exams, excluding young or systemically ill cats.
- Echocardiography (2D, M-mode, Doppler) performed to evaluate cardiac structures and blood flow.
Main Results:
- Fifty-seven cats were included; all murmurs were systolic.
- Dynamic outflow tract obstruction (left, right, or combined) caused 79% of murmurs.
- Heart disease, primarily left ventricular hypertrophy, was present in 88% of cats.
Conclusions:
- Most heart murmurs in apparently healthy cats stem from dynamic outflow tract obstruction.
- The presence of a heart murmur in a healthy cat strongly suggests underlying heart disease.
- Echocardiography is essential for diagnosing the cause of murmurs and identifying heart disease in cats.
Abstract:
Heart murmurs are caused by turbulent blood flow or by vibration of cardiac structures. Turbulent blood flow may originate from structural heart disease or from physiological phenomena. The aims of this study were to establish the cause of heart murmurs in apparently healthy adult cats and to determine whether a heart murmur is a reliable indicator of heart disease. In this retrospective study, we reviewed the medical records of cats in which a heart murmur was detected during physical examination by one of the authors in the period January 2008 to December 2009. Cats younger than 6 months and those with systemic disease were excluded. Timing, grade, and point of maximum intensity of the murmur were determined by one observer (MD) before 2D-, M-mode and Doppler echocardiography. Fifty-seven cats (median age 76 months, range 6-194) were included, 30 neutered females and 27 neutered males. All murmurs were systolic and varied in intensity from 2/6 to 5/6. The point of maximum intensity was the left or right parasternal region in 34/57 (61%) of murmurs. Murmurs were caused by dynamic left ventricular outflow tract obstruction in 25/57 (44%) cats, dynamic right ventricular outflow tract obstruction in 9/57 (16%) cats, and combined dynamic left and right outflow tract obstruction in 11/57 (19%) cats. In 5 (9%) cats the cause of the murmur could not be identified. Heart disease was present in 50 (88%) cats, namely, left ventricular hypertrophy in 44 (77%) and congenital defects in 6 (11%) cats. In conclusion, most heart murmurs in apparently healthy cats are detected in the left or right parasternal region and are caused by dynamic left and right ventricular outflow tract obstruction. Because most cats (88%) with a heart murmur had heart disease in this study, if a heart murmur is detected in an apparently healthy cat, echocardiography is recommended to determine the cause of the heart murmur and the presence of heart disease.
Related Concept Videos
Cardiovascular System Abnormal Findings II: Auscultation
Abnormal Heart Sounds
Gallops:
Heart Sounds
Auscultation is the process of listening to these internal body sounds using a stethoscope. The heart produces four types of sounds, but only two—S1 and S2—can usually be heard with a stethoscope.
S1, also known as the "lub" sound, is caused by the closure of atrioventricular (A-V) valves at the...
Cardiomyopathy III: Hypertrophic Cardiomyopathy
Aortic Regurgitation II: Clinical Features and Diagnostic Tests
Mitral Stenosis II: Clinical features and Diagnostic Tests
Mitral Regurgitation II: Clinical Features and Diagnostic Tests

