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Health related quality of life in patients with Cohn´s disease in remission

M Iglesias1, I Vázquez, M Barreiro-de Acosta

  • 1Fienad Clinic University Hospital of Santiago.

Revista Espanola De Enfermedades Digestivas
|December 15, 2010
PubMed

Insights

Crohn's disease patients in remission still experience reduced health-related quality of life (HRQoL). Factors like age and surgery impact HRQoL, while education and time since diagnosis may improve it.

Area of Science:

  • Gastroenterology
  • Clinical Medicine
  • Health Outcomes Research

Background:

  • Crohn's disease (CD) significantly impacts health-related quality of life (HRQoL), particularly during active phases.
  • The effect of CD on HRQoL during remission periods remains understudied.

Purpose of the Study:

  • To assess HRQoL in Crohn's disease patients currently in remission.
  • To identify demographic and clinical factors associated with HRQoL in these patients.

Main Methods:

  • Included 92 CD patients in remission (CDAI < 150, CRP < 5 mg/L) for at least 6 months.
  • Collected socio-demographic and clinical data.
  • Administered the Short Form 36 (SF-36) and Inflammatory Bowel Disease Questionnaire (IBDQ) for HRQoL assessment.
  • Analyzed data using multiple regression with 95% confidence intervals.

Main Results:

  • CD patients in remission reported lower SF-36 scores compared to the general population.
  • General Health (SF-36) and Systemic Symptoms (IBDQ) were the most affected dimensions.
  • Worse HRQoL was linked to younger age, colonic disease location, and prior surgery.
  • Higher education, longer disease duration, steroid-resistance, and inflammatory behavior correlated with better HRQoL.

Conclusions:

  • Crohn's disease patients experience diminished HRQoL even during remission.
  • Continued efforts are necessary to enhance HRQoL for CD patients throughout all disease stages.
Abstract

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