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Updated: Jun 6, 2026

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Multifocal intradural extramedullary ependymoma. Case report.

Eduardo Augusto Iunes1, João Norberto Stávale, Rita de Cássia Caldas Pessoa

  • 1Departments of Neurology and NeurosurgeryUniversidade Federal de São Paulo, Brazil. eaiunes@ig.com.br

Journal of Neurosurgery. Spine
|December 15, 2010
PubMed
Summary

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This study reports the first case of multifocal intradural extramedullary ependymoma, a rare spinal tumor. Prognosis depends on tumor resection extent and meningeal infiltration.

Area of Science:

  • Neuro-oncology
  • Spinal cord pathology
  • Neurosurgery

Background:

  • Intradural extramedullary ependymomas are rare spinal tumors.
  • This study reviews 19 cases, including a novel multifocal presentation.

Observation:

  • The case involved a 32-year-old male with multifocal lesions across the neuraxis.
  • Histopathology confirmed WHO Grade II ependymoma.
  • Literature review identified 18 prior cases, none multifocal at initial diagnosis.

Findings:

  • Multifocal intradural extramedullary ependymomas predominantly affect women in their 5th decade.
  • Pain and medullary syndrome are common initial symptoms.
  • Thoracic spine is the most frequent tumor location.

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Implications:

  • Complete tumor resection and absence of meningeal infiltration are crucial for favorable prognosis.
  • This case expands the understanding of ependymoma presentation and behavior.
  • Further research is needed to elucidate the pathogenesis of multifocal spinal ependymomas.