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Assessing Cerebral Autoregulation via Oscillatory Lower Body Negative Pressure and Projection Pursuit Regression
Published on: December 10, 2014
Relations between beat-to-beat microcirculatory blood flow and variations therein
Hsin Hsiu1, Chia-Liang Hsu, Ming-Yie Jan
1Department of Electrical Engineering, Yuan Ze University, Taoyuan, Taiwan, ROC. hhsiu@saturn.yzu.edu.tw
Photomedicine and Laser Surgery
|December 15, 2010
Summary
Beat-to-beat analysis of microcirculatory blood flow (MBF) and its variations (MBFV) using laser Doppler flowmetry (LDF) reveals a relationship between flow and variability. This method may help assess treatments for improving microcirculation.
Area of Science:
- Physiology
- Cardiovascular Science
- Microcirculation Research
Background:
- Beat-to-beat cardiovascular variability offers insights into autonomic control.
- Laser Doppler flowmetry (LDF) measures microcirculatory blood flow (MBF).
Purpose of the Study:
- To investigate changes in MBF and microcirculatory blood flow variability (MBFV) using LDF and beat-to-beat analysis.
- To elucidate the impact of local heating stimulation on MBF and MBFV.
Main Methods:
- Nonpainful local heating applied for 20 minutes, segmented into four measurements (M1-M4).
- Calculated DCflux (average LDF flux) per pulse.
- Evaluated beat-to-beat MBFV using the coefficient of variance of DCflux (DCCV).
Main Results:
- Linear regression analysis showed negative slopes between relative changes in DCCV and DCflux.
- A negative relationship was observed between preceding DCCV and subsequent DCflux (R(2) > 0.40, p < 0.05).
Conclusions:
- First study to demonstrate a time-domain relationship between MBF and MBFV parameters.
- MBFV from beat-to-beat LDF waveform is valuable for monitoring microcirculatory regulatory activities.
- This approach may aid in evaluating treatments targeting microcirculatory perfusion.
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01:29Blood Flow
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01:20Regulation of Pulse
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