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[Risks of cyclosporine therapy in paediatric age]

João Antunes1, Catarina Gouveia, Maria João Brito

  • 1Serviços de Imunoalergologia, Unidade de Infecciologia, Hospital Dona Estefânia, Lisboa.

Acta Medica Portuguesa
|December 15, 2010
PubMed

Insights

Cyclosporine is effective for pediatric inflammatory skin conditions but carries risks. Careful monitoring is essential due to potential side effects like infections and organ impairment in children.

Area of Science:

  • Pediatric Dermatology
  • Immunosuppressive Therapy

Background:

  • Cyclosporine is recognized for treating inflammatory skin disorders in adults and children.
  • Its pediatric application requires further investigation and cautious consideration.

Observation:

  • Three pediatric cases (atopic dermatitis and psoriasis) treated with oral cyclosporine are presented.
  • Patients experienced adverse events including impetigo, herpetic infection, hepatic, and renal impairment.

Findings:

  • Adverse events necessitated treatment cessation in all three pediatric patients.
  • Potential drug interactions and cyclosporine toxicity were noted.
  • Complications included secondary impetigo, herpetic infections, and organ dysfunction.

Implications:

  • Data on cyclosporine use in children remains limited.
  • Cyclosporine in pediatric patients should be reserved for specific indications.
  • Risk-benefit assessment and vigilant monitoring are crucial for safe utilization.
Abstract

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