Related Experiment Video
Updated: Jun 6, 2026
06:35
An Immunohistopathologic Study to Profile the Folate Receptor Beta Macrophage and Vascular Immune Microenvironment in Giant Cell Arteritis
Published on: February 8, 2019
[Undifferentiated osteoclastic-type giant cell carcinoma]
Ana Pimentel1, Sara Leitão, Nuno Dias
1Serviços de Medicina III, Cirurgia III e Anatomia Patológica dos Hospitais da Universidade de Coimbra, Coimbra.
Acta Medica Portuguesa
|December 15, 2010
Summary
Undifferentiated osteoclastic-type giant cell carcinoma (IOGCC) is a rare pancreatic cancer variant. This case highlights diagnostic and therapeutic challenges for this uncommon exocrine pancreatic tumor.
Area of Science:
- Oncology
- Gastroenterology
- Pathology
Background:
- Undifferentiated osteoclastic-type giant cell carcinoma (IOGCC) is an extremely rare variant of pancreatic ductal adenocarcinoma, accounting for less than 1% of exocrine pancreatic tumors.
- Its rarity results in limited clinical experience and ongoing debate regarding its histogenesis, diagnostic approaches, and treatment strategies.
Observation:
- A 61-year-old patient presented with a large left hypochondrium abdominal mass and microcytic anemia.
- Diagnostic investigations revealed a pancreatic neoplasm.
- The patient underwent surgical resection for the tumor.
Findings:
- Anatomopathological study confirmed the diagnosis of IOGCC.
- The case highlights a rare presentation of pancreatic cancer.
Implications:
- This report contributes to the limited existing literature on IOGCC.
- It underscores the importance of considering rare diagnoses in pancreatic oncology.
- Further research into IOGCC's unique characteristics and optimal management is warranted.
Related Concept Videos
01:30Bone Cells and Tissue
Bones contain a relatively small number of cells entrenched in a matrix of organic and inorganic components. Although bone cells compose only a small amount of the bone volume, they are crucial to its function. Four types of cells are found within the bone tissue— osteoblasts, osteocytes, osteogenic cells, and osteoclasts.
Osteoblasts and Osteocytes
The osteoblast is the bone cell responsible for forming new bone tissue. It is found in the growing portions of bone, including the periosteum and...
Osteoblasts and Osteocytes
The osteoblast is the bone cell responsible for forming new bone tissue. It is found in the growing portions of bone, including the periosteum and...
01:31Osteoclasts in Bone Remodeling
Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...