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Updated: Jun 6, 2026

Laparoscopic Oocyte Retrieval and Cryopreservation during Vaginoplasty for Treatment of Mayer-Rokitansky-Kuster-Hauser Syndrome
Published on: May 10, 2022
In vitro fertilization surrogacy in rare coexisting Mayer-Rokitansky-Kuster-Hauser syndrome and triple X karyotype
Arieh Raziel1, Shevach Friedler, Yariv Gidoni
1The IVF Unit, Assaf Harofeh Medical Center, Zerifin, Israel. araziel@asaf.health.gov.il
Objective:
To report the responses to IVF surrogacy attempts in a female with a heretofore never described combination of Mayer-Rokitansky-Kuster-Hauser (MRHK) syndrome and triple X karyotype.
Design:
Case report.
Setting:
Reproductive unit of a university-affiliated medical center.
Patient(S):
A 29-year-old female diagnosed as having both MRHK syndrome and a triple X (47XXX) karyotype.
Intervention(S):
Five cycles of IVF surrogacy.
Main Outcome Measure(S):
Recovery of oocytes after controlled ovarian stimulation.
Result(S):
A maximum of five oocytes were retrieved by percutaneous abdominal aspiration of a single subcostal left ovary. After five unsuccessful IVF trials due to low ovarian response attributed to her coexisting MRHK syndrome and triple X karyotype, the patient's choice was oocyte donation.
Conclusion(S):
An abnormal karyotype can coexist with MRKH syndrome, albeit very rarely, and probably accounts for a low ovarian response to attempts to achieve IVF surrogacy.
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