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Updated: Jun 6, 2026

In Vitro Differentiation Model of Human Normal Memory B Cells to Long-lived Plasma Cells
Published on: January 20, 2019
B cell memory and the role of apoptosis in its formation
Ingela Vikstrom1, David M Tarlinton
1The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3052, Australia.
Abstract:
B cell memory consists of quiescent memory B cell and bone marrow plasma cell populations, generated in germinal centers during immune responses to T cell dependent antigens. The regulation of cell survival, both within germinal centers and in the maintenance of the effector cells generated in this response, is central to the qualitative and quantitative regulation of memory. In spite of this, the pro- and anti-apoptotic molecules that control survival in these peri-antigenic B cell immune compartments are poorly defined. In this review, we discuss the current perception of the main apoptotic regulators of germinal center B cell, plasma cell, and memory B cell survival during the formation, affinity maturation and maintenance of immunological memory.
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