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Elevated serum chemerin concentrations are associated with renal dysfunction in type 2 diabetic patients
1Department of Endocrinology, General Hospital of Tianjin Medical University, 154 Anshan Street, Heping District, 300052, Tianjin, PR China.
Diabetes Research and Clinical Practice
|December 15, 2010
Summary
Serum chemerin levels are elevated in type 2 diabetes patients with advanced kidney disease. This adipocytokine is strongly linked to impaired renal function in diabetic nephropathy.
Area of Science:
- Endocrinology
- Nephrology
- Metabolic Syndrome
Background:
- Chemerin, an adipocytokine, is implicated in insulin resistance and type 2 diabetes.
- The relationship between chemerin and diabetic nephropathy remains unclear.
Purpose of the Study:
- To investigate the association between plasma chemerin levels and renal function in type 2 diabetic patients.
- To determine if chemerin levels differ based on the presence and severity of diabetic nephropathy.
Main Methods:
- Enzyme-linked immunosorbent assay (ELISA) was used to measure serum chemerin levels.
- Study included 116 type 2 diabetic patients and 38 healthy controls.
Main Results:
- Serum chemerin was significantly higher in diabetic patients with macroalbuminuria compared to controls and those with normo/microalbuminuria.
- Chemerin levels positively correlated with age, BMI, SBP, CRP, BUN, serum creatinine, and triglycerides.
- Chemerin negatively correlated with creatinine clearance, which remained a significant predictor in regression analysis.
Conclusions:
- Serum chemerin levels are strongly associated with renal function in diabetic patients.
- Elevated chemerin may serve as a biomarker for diabetic nephropathy progression.
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