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Related Concept Videos

The Tumor Microenvironment02:17

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
The Tumor Microenvironment02:17

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
Inflammation: Introduction01:28

Inflammation: Introduction

Inflammation is a fundamental, protective biological response of vascularized tissues to cellular injury, infection, or harmful stimuli. Its primary function is to eliminate the initial cause of injury, clear necrotic cells and damaged tissue, and initiate the necessary repair processes.Cardinal SignsAcute inflammation presents with classic signs. Redness results from vasodilation and increased blood flow. Heat is due to increased metabolism and circulation. Swelling results from the...
Chronic Inflammation: Introduction01:12

Chronic Inflammation: Introduction

Chronic inflammation is a prolonged, dysregulated immune response that persists for weeks to years when the inciting stimulus is difficult to eradicate or when self‑antigens drive ongoing reactivity. Morphologically, it is defined by mononuclear cell infiltration, progressive tissue destruction, and concurrent attempts at healing via angiogenesis and fibrosis. Compared with acute inflammation, edema is less prominent while cellular infiltration predominates; triggers include persistent...
Inflammatory Bowel Disease III: Crohn's Disease01:25

Inflammatory Bowel Disease III: Crohn's Disease

Crohn’s disease is a chronic, relapsing form of inflammatory bowel disease characterized by segmental, transmural inflammation that can affect any part of the gastrointestinal tract. Its pathogenesis arises from a combination of genetic susceptibility, environmental exposures, epithelial barrier dysfunction, and immune dysregulation. Together, these factors lead to an exaggerated immune response against components of the gut microbiome.Genetic and Environmental InfluencesMultiple genetic...
Inflammation01:38

Inflammation

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Updated: Jun 6, 2026

Phospholipid Mediator Induced Transformation in Three-Dimensional Cultures
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Phospholipid Mediator Induced Transformation in Three-Dimensional Cultures

Published on: July 27, 2022

Environment, inflammation, and cancer.

Pasquale Sansone1, Jacqueline Bromberg

  • 1Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA.

Current Opinion in Genetics & Development
|December 15, 2010
PubMed
Summary

Inflammation is critical in tumor development, influencing cancer progression. Understanding these inflammatory roles reveals new therapeutic targets for cancer treatment.

Area of Science:

  • Oncology
  • Immunology
  • Cancer Research

Background:

  • Rudolf Virchow first suggested leukocytes in tumors indicate inflammation's role in tumorigenesis.
  • Current data confirm a strong link between inflammatory responses and tumor development stages.

Purpose of the Study:

  • To review key molecular and cellular events in inflammation-driven tumorigenesis.
  • To highlight novel therapeutics targeting inflammation in cancer treatment.

Main Methods:

  • Literature review of experimental and clinical data.
  • Analysis of molecular and cellular mechanisms.
  • Examination of therapeutic strategies.

Main Results:

  • Inflammation plays a critical role in promoting tumorigenesis.

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Characterization of Immune Cells and Proinflammatory Mediators in the Pulmonary Environment

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Phospholipid Mediator Induced Transformation in Three-Dimensional Cultures
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Published on: July 27, 2022

Characterization of Immune Cells and Proinflammatory Mediators in the Pulmonary Environment
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Characterization of Immune Cells and Proinflammatory Mediators in the Pulmonary Environment

Published on: June 24, 2020

  • The dynamic interplay between tumor, immune, and mesenchymal cells is crucial for cancer progression.
  • Novel therapeutic targets are emerging from this understanding.

    • Conclusions:

    • Inflammation is a key driver of cancer development.
    • Targeting inflammatory pathways offers promising therapeutic avenues.
    • Further research into these interactions may lead to clinical success.