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Regulation of Angiogenesis and Blood Supply

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Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits. Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl hydroxylase and factor...

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Related Experiment Video

Updated: Jun 6, 2026

Trophoblast Cell Recovery from Angiogenesis-Tube Formation Assay for Differentiation Marker Expression Analysis

Trophoblast Cell Recovery from Angiogenesis-Tube Formation Assay for Differentiation Marker Expression Analysis

Published on: November 8, 2024

Decidualisation and angiogenesis.

Margreet Plaisier¹

¹Leiden University Medical Centre, PO Box 9600, 2300 RC Leiden, The Netherlands. Margreetp@hotmail.com

Best Practice & Research. Clinical Obstetrics & Gynaecology

|December 15, 2010

Summary

Proper decidual vascular changes during early pregnancy are crucial for successful implantation. Disruptions in these vascular processes are linked to pregnancy complications like miscarriage and pre-eclampsia.

Area of Science:

Reproductive Biology
Vascular Biology
Obstetrics

Background:

Endometrial transformation during the secretory phase is vital for implantation, involving vascular remodelling and decidualisation.
Decidualisation involves stromal cell differentiation, immune cell infiltration, and vascular adaptation, including angiogenesis.
Uterine blood supply disturbances correlate with adverse pregnancy outcomes such as miscarriage, pre-eclampsia, and fetal growth restriction.

Purpose of the Study:

To assess decidual vascular changes during human implantation.
To evaluate the role of angiogenesis in pregnancy complications.

Main Methods:

Review of literature on decidualisation and vascular changes during human implantation.
Analysis of the involvement of angiogenesis in miscarriage, pre-eclampsia, and intrauterine growth restriction.

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Isolation of Primary Human Decidual Cells from the Fetal Membranes of Term Placentae

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Main Results:

Decidualisation involves significant vascular remodelling, increased permeability, and angiogenesis.
Impaired vascular adaptation and angiogenesis are implicated in the pathogenesis of pregnancy disorders.

Conclusions:

Precise timing of decidual vascular changes is essential for a receptive endometrium.
Angiogenesis plays a critical role in normal implantation and its dysregulation contributes to pregnancy pathologies.