Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cell Adhesion Molecules - Types and Functions01:20

Cell Adhesion Molecules - Types and Functions

Cell adhesion molecules (CAMs) are pivotal to multicellularity and the coordinated functioning of tissues and organ systems. They enable physical interactions between cells and provide mechanical strength to tissues. They also function as receptors for signal transmission across the plasma membrane. The CAMs are broadly classified into four families - integrins, cadherins, selectins, and immunoglobulin-like CAMs (IgCAMs).
CAM Families
The Integrin family of proteins is primarily  involved in a...
Cell Adhesion Molecules - Types and Functions01:20

Cell Adhesion Molecules - Types and Functions

Cell adhesion molecules (CAMs) are pivotal to multicellularity and the coordinated functioning of tissues and organ systems. They enable physical interactions between cells and provide mechanical strength to tissues. They also function as receptors for signal transmission across the plasma membrane. The CAMs are broadly classified into four families - integrins, cadherins, selectins, and immunoglobulin-like CAMs (IgCAMs).
CAM Families
The Integrin family of proteins is primarily  involved in a...
Neuroplasticity01:01

Neuroplasticity

Neuroplasticity reflects the brain's remarkable capacity to adapt and evolve, responding dynamically to learning, experiences, or injury by reorganizing its neural circuitry. This reorganization involves creating new neural connections and refining old ones through a series of biological processes that contribute to the brain's lifelong development and adaptability.
Immunoglobulin-like Cell Adhesion Molecules01:31

Immunoglobulin-like Cell Adhesion Molecules

Immunoglobulin-like cell adhesion molecules or Ig-CAMs are a versatile group of cell surface glycoproteins belonging to the immunoglobulin protein superfamily. Ig-CAMs possess the characteristic immunoglobulin protein domains and other domains such as the fibronectin type III domain. The Ig domains are glycosylated to varying degrees in different Ig-CAMs.
Ig-CAMs exhibit either homophilic binding (to other Ig-CAMs) or heterophilic binding (to other ligands such as integrins). While most Ig-CAMs...
Chemical Synapses01:26

Chemical Synapses

Chemical synapses are specialized sites between two neurons or between a neuron and a non-neuronal cell like a muscle, glandular or sensory cell.
Because chemical synapses depend on the release of neurotransmitter molecules from synaptic vesicles to pass on their signal, there is an approximately one millisecond delay between when the axon potential reaches the presynaptic terminal and when the neurotransmitter leads to opening of postsynaptic ion channels. Additionally, this signaling is...
Chemical Synapses01:26

Chemical Synapses

Chemical synapses are specialized sites between two neurons or between a neuron and a non-neuronal cell like a muscle, glandular or sensory cell.
Because chemical synapses depend on the release of neurotransmitter molecules from synaptic vesicles to pass on their signal, there is an approximately one millisecond delay between when the axon potential reaches the presynaptic terminal and when the neurotransmitter leads to opening of postsynaptic ion channels. Additionally, this signaling is...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

All-optical visualization of specific molecules in the ultrastructural context of brain tissue.

Nature biotechnology·2025
Same author

A multicenter study to assess the performance of the point-of-care RT-PCR Cobas SARS-CoV-2 & Influenza A/B nucleic acid test for use on the Cobas Liat system in comparison with centralized assays across healthcare facilities in the United States.

Journal of clinical microbiology·2025
Same author

High-content image-based pooled screens reveal regulators of synaptogenesis.

Cell reports·2025
Same author

Progressive vulnerability of cortical synapses in α-synucleinopathy.

bioRxiv : the preprint server for biology·2025
Same author

Corrigendum to "Oxidative stress activates the c-Abl/p73 proapoptotic pathway in Niemann-Pick type C neurons" [Neurobiology of Disease Volume 41, Issue 1, January 2011, Pages 209-218].

Neurobiology of disease·2025
Same author

Transition State Analysis of SAMHD1 from Primary <sup>18</sup>O, <sup>33</sup>P, and Solvent Kinetic Isotope Effects.

Journal of the American Chemical Society·2025

Related Experiment Video

Updated: Jun 6, 2026

Evaluation of Synapse Density in Hippocampal Rodent Brain Slices
07:44

Evaluation of Synapse Density in Hippocampal Rodent Brain Slices

Published on: October 6, 2017

SynCAM 1 adhesion dynamically regulates synapse number and impacts plasticity and learning.

Elissa M Robbins1, Alexander J Krupp, Karen Perez de Arce

  • 1Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06520, USA.

Neuron
|December 15, 2010
PubMed
Summary
This summary is machine-generated.

Synaptic cell adhesion molecule 1 (SynCAM 1) regulates excitatory synapse number and plasticity in the brain. Loss of SynCAM 1 improves spatial learning, while its overexpression impairs it, revealing its role in neuronal network remodeling.

More Related Videos

Quantifying Synapses: an Immunocytochemistry-based Assay to Quantify Synapse Number
18:11

Quantifying Synapses: an Immunocytochemistry-based Assay to Quantify Synapse Number

Published on: November 16, 2010

Presynaptically Silent Synapses Studied with Light Microscopy
11:02

Presynaptically Silent Synapses Studied with Light Microscopy

Published on: January 4, 2010

Related Experiment Videos

Last Updated: Jun 6, 2026

Evaluation of Synapse Density in Hippocampal Rodent Brain Slices
07:44

Evaluation of Synapse Density in Hippocampal Rodent Brain Slices

Published on: October 6, 2017

Quantifying Synapses: an Immunocytochemistry-based Assay to Quantify Synapse Number
18:11

Quantifying Synapses: an Immunocytochemistry-based Assay to Quantify Synapse Number

Published on: November 16, 2010

Presynaptically Silent Synapses Studied with Light Microscopy
11:02

Presynaptically Silent Synapses Studied with Light Microscopy

Published on: January 4, 2010

Area of Science:

  • Neuroscience
  • Molecular Biology
  • Developmental Biology

Background:

  • Synaptogenesis is crucial for establishing and refining neuronal circuits in both developing and adult brains.
  • The molecular mechanisms governing synapse development and maintenance in vivo are not fully understood.

Purpose of the Study:

  • To investigate the role of the immunoglobulin adhesion molecule SynCAM 1 in regulating synapse number and plasticity.
  • To determine the impact of SynCAM 1 on neuronal connectivity and learning.

Main Methods:

  • Utilized transgenic mice with SynCAM 1 overexpression and knockout models.
  • Assessed changes in excitatory synapse number and plasticity.
  • Evaluated spatial learning abilities in different mouse models.

Main Results:

  • SynCAM 1 overexpression increased excitatory synapse number; SynCAM 1 loss reduced it.
  • SynCAM 1 was shown to maintain newly induced synapses.
  • SynCAM 1 regulated synaptic plasticity, specifically long-term depression, at mature synapses.
  • SynCAM 1 knockout mice exhibited improved spatial learning compared to controls.

Conclusions:

  • SynCAM 1 dynamically regulates synapse number and plasticity.
  • This adhesion molecule plays a significant role in activity-dependent neuronal network remodeling.
  • SynCAM 1 influences spatial learning, with its absence enhancing performance.